Adgrl4 adhesion G protein-coupled receptor L4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adgrl4provided by MGI
Official Full Name: adhesion G protein-coupled receptor L4provided by MGI
Primary source: MGI:MGI:2655562
See related: Ensembl:ENSMUSG00000039167 AllianceGenome:MGI:2655562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Etl; ETL1; Eltd1; 1110033N21Rik
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and protein-containing complex assembly. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Is expressed in cardiovascular system; lung; metanephros; and skeletal muscle. Orthologous to human ADGRL4 (adhesion G protein-coupled receptor L4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 19.1), subcutaneous fat pad adult (RPKM 9.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 76.76 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (151143519..151250718)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (151437882..151545081)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
Title: ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma.
loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
Title: Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).
ELTD1 deficiency exacerbates cardiac hypertrophy and cardiac function induced by aortic banding-induced pressure overload by promoting both cardiomyocyte hypertrophy and cardiac fibrosis.
Title: Augmented cardiac hypertrophy in response to pressure overload in mice lacking ELTD1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor L4

Names: EGF, latrophilin seven transmembrane domain containing 1; EGF, latrophilin seven transmembrane domain-containing protein 1; EGF-TM7 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133222.3 → NP_573485.2 adhesion G protein-coupled receptor L4 precursor

See identical proteins and their annotated locations for NP_573485.2

Status: VALIDATED

Source sequence(s)

AC127233

Consensus CDS

CCDS17910.1

UniProtKB/Swiss-Prot

E9QLT4, Q91W44, Q923X1

Related

ENSMUSP00000041939.8, ENSMUST00000046977.12

Conserved Domains (4) summary

smart00179
Location:58 → 91

EGF_CA; Calcium-binding EGF-like domain

pfam01825
Location:417 → 461

GPS; GPCR proteolysis site, GPS, motif

pfam16489
Location:190 → 370

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl21561
Location:473 → 709

7tm_4; Olfactory receptor