Fev FEV transcription factor, ETS family member [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fevprovided by MGI
Official Full Name: FEV transcription factor, ETS family memberprovided by MGI
Primary source: MGI:MGI:2449712
See related: Ensembl:ENSMUSG00000055197 AllianceGenome:MGI:2449712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pet1; Pex1; Pet-1; mPet-1
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within maternal behavior; neuron differentiation; and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including aorta-gonad-mesonephros; liver; and nervous system. Orthologous to human FEV (FEV transcription factor, ETS family member). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 1.0), testis adult (RPKM 1.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1; 1 C4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74920660..74924632, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74881501..74885473, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
Title: Neurochemically and Hodologically Distinct Ascending VGLUT3 versus Serotonin Subsystems Comprise the r2-Pet1 Median Raphe.
serotonergic neurons, phrenic discharge in eupnea and gasping of Pet-1 knockout mice was not different from that of wild-type mice
Title: Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse.
Pet-1 knockout induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness.
Title: Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness.
Remaining 5-HT neurons in Pet1 null mice outline a unique subpopulation of raphe neurons with highly selective anatomical targets and characteristic synaptic differentiations
Title: A genetically defined morphologically and functionally unique subset of 5-HT neurons in the mouse raphe nuclei.
only male Pet-1 null mice showed a significant deficit in the hypercapnic ventilatory response when expressed as % of control
Title: Altered ventilatory and thermoregulatory control in male and female adult Pet-1 null mice.
Pet-1 knockout mice show significantly decreased phase delays of the circadian clock in response to light pulses in the early night
Title: Photic and nonphotic responses of the circadian clock in serotonin-deficient Pet-1 knockout mice.
Pet-1 regulation of raphe neuron serotonin phenotype contributes to the period, precision and light/dark partitioning of locomotor behavioral rhythms by the circadian clock through direct actions on the SCN clock itself and through non-clock effects
Title: Pet-1 deficiency alters the circadian clock and its temporal organization of behavior.
Thus, Pet1(210)-Cre transgenic mouse line faithfully drives Cre-mediated recombination in all Pet1 expression domains representing a valuable tool to genetically manipulate serotonergic and non-serotonergic Pet1 cell lineages.
Title: Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery.
Findings indicated that while some 5-HT neurons are not absolutely dependent on Pet-1 for expression of Tph2 virtually all dorsal raphe 5-HT neurons require Pet-1 for expression of other key identity genes
Title: Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons.
Pet1 knockout leads to significant changes of cell-intrinsic excitability in cortical pyramidal cells and increase in spontaneous synaptic excitation through 5-HT3 receptors.
Title: Abnormal cell-intrinsic and network excitability in the neocortex of serotonin-deficient Pet-1 knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489526

NoName (e-PCR)
- UniSTS:495675

Fev (e-PCR), detects polymorphism
- UniSTS:547219

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	NAS Non-traceable Author Statement more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of serotonin biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of serotonin uptake	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in neuronal cell body	TAS Traceable Author Statement more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein FEV

Names: ETS-domain transcription factor Pet-1; FEV (ETS oncogene family); FEV (fifth Ewing variant); PC12 ETS domain-containing transcription factor 1; PC12 ETS factor 1; pheochromocytoma 12 ETS (E26 transformation-specific); plasmacytoma expressed transcript 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.