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    Tfap2d transcription factor AP-2, delta [ Mus musculus (house mouse) ]

    Gene ID: 226896, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tfap2dprovided by MGI
    Official Full Name
    transcription factor AP-2, deltaprovided by MGI
    Primary source
    MGI:MGI:2153466
    See related
    Ensembl:ENSMUSG00000042596 AllianceGenome:MGI:2153466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcfap2d
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within inferior colliculus development; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including brain; ganglia; genitourinary system; heart; and retina. Orthologous to human TFAP2D (transcription factor AP-2 delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 3.9), CNS E18 (RPKM 3.2) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tfap2d in Genome Data Viewer
    Location:
    1 A3; 1 6.08 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (19173246..19244172)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (19103022..19173948)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24075 Neighboring gene predicted gene 28343 Neighboring gene predicted gene 15825 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene transcription factor AP-2 beta Neighboring gene 60S ribosomal protein L17-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The effect of AP-2δ on transcription of the Prestin gene in HEI-OC1 cells upon oxidative stress. Luo X, et al. Cell Mol Biol Lett, 2019. PMID 31297132, Free PMC Article
    2. The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade. Tran HN, et al. Cell Death Differ, 2023 Jun. PMID 37081114, Free PMC Article
    3. Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties. Zhao F, et al. J Biol Chem, 2001 Nov 2. PMID 11522791
    4. Expression of Tfap2d, the gene encoding the transcription factor Ap-2 delta, during mouse embryogenesis. Zhao F, et al. Gene Expr Patterns, 2003 May. PMID 12711551
    5. Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Tan CC, et al. Proc Natl Acad Sci U S A, 2008 May 27. PMID 18495928, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2delta transcriptional cascade.
      Title: The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade.
    2. Oxidative stress inhibits the expression of Prestin protein, and the transcription mechanism is triggered to compensate for the loss of Prestin protein in HEI-OC1 cells. AP-2delta is one of the important TFs that suppresses transcription of the Prestin gene, and AP-2delta suppression further boosted Prestin mRNA activation under oxidative stress.
      Title: The effect of AP-2δ on transcription of the Prestin gene in HEI-OC1 cells upon oxidative stress.
    3. AP-2delta is important for the maintenance of ganglion cell numbers in the retina.
      Title: Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus.
    4. Data show that Ap-2delta occupies and activates the Pou4f3 and Bhlhb4 promoters.
      Title: AP-2δ is a crucial transcriptional regulator of the posterior midbrain.
    5. Several candidate targets of complexes containing Ap2delta and Ash2l were identified that can be used to further elucidate their roles during development and showed that Fgfr3 is a novel direct target of these complexes.
      Title: Fgfr3 is a transcriptional target of Ap2delta and Ash2l-containing histone methyltransferase complexes.
    6. Ap2delta associates with ASH2L and MLL2 (ALR), forming a complex that methylates lysine 4 of histone H3.
      Title: Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inferior colliculus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor AP-2-delta
    Names
    AP2-delta
    activating enhancer-binding protein 2-delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379073.1 → NP_001366002.1  transcription factor AP-2-delta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC098736
      Conserved Domains (1) summary
      pfam03299
      Location:215 → 409
      TF_AP-2; Transcription factor AP-2

    2. NM_001379074.1 → NP_001366003.1  transcription factor AP-2-delta isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC098736
      Conserved Domains (1) summary
      pfam03299
      Location:187 → 381
      TF_AP-2; Transcription factor AP-2

    3. NM_153154.3 → NP_694794.1  transcription factor AP-2-delta isoform 1

      See identical proteins and their annotated locations for NP_694794.1

      Status: VALIDATED

      Source sequence(s)
      AC098736, AF421891, BB676311, CO424726
      Consensus CDS
      CCDS14838.1
      UniProtKB/Swiss-Prot
      A7MCU6, Q91ZK0
      Related
      ENSMUSP00000037699.8, ENSMUST00000037294.8
      Conserved Domains (1) summary
      pfam03299
      Location:211 → 405
      TF_AP-2; Transcription factor AP-2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      19173246..19244172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495498.4 → XP_006495561.1  transcription factor AP-2-delta isoform X1

      See identical proteins and their annotated locations for XP_006495561.1

      Conserved Domains (1) summary
      pfam03299
      Location:187 → 381
      TF_AP-2; Transcription factor AP-2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZK0.1 GenPept UniProtKB/Swiss-Prot:Q91ZK0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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