Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Muc5acprovided by MGI
Official Full Name: mucin 5, subtypes A and C, tracheobronchial/gastricprovided by MGI
Primary source: MGI:MGI:104697
See related: Ensembl:ENSMUSG00000037974 AllianceGenome:MGI:104697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MGM; 2210005L13Rik
Summary: Acts upstream of or within maintenance of lens transparency. Located in extracellular space. Is expressed in male reproductive gland or organ; nasal cavity epithelium; respiratory system; and stomach. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and dry eye syndrome. Orthologous to human MUC5AC (mucin 5AC, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward stomach adult (RPKM 445.3) See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.23 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141342695..141372964)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141788958..141819227)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective role of overexpressed MUC5AC against fibrosis in MHV-68-induced combined pulmonary fibrosis and emphysema mouse model.
Title: Protective role of overexpressed MUC5AC against fibrosis in MHV-68-induced combined pulmonary fibrosis and emphysema mouse model.
House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
Title: House dust mite-induced endoplasmic reticulum stress mediates MUC5AC hypersecretion via TBK1 in airway epithelium.
[Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
Title: [Dickkopf-1 inhibits the secretion of MUC5AC induced by Mycoplasma pneumoniae P1-C in mouse lung epithelial cells].
De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
Title: De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
Title: Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
Title: Mucin 5AC-Mediated CD44/ITGB1 Clustering Mobilizes Adipose-Derived Mesenchymal Stem Cells to Modulate Pancreatic Cancer Stromal Heterogeneity.
Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
Title: Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease.
Mucin 5AC Serves as the Nexus for beta-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
Title: Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.
Title: Porphyromonas gingivalis gingipains potentially affect MUC5AC gene expression and protein levels in respiratory epithelial cells.
Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.
Title: Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Muc5ac (e-PCR), detects polymorphism
- UniSTS:530707

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within maintenance of lens transparency	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in mucus layer	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-5AC

Names: gastric mucin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010844.3 → NP_034974.2 mucin-5AC precursor

Status: VALIDATED

Source sequence(s)

AC175658, AC175742

UniProtKB/TrEMBL

E9QAQ8

Conserved Domains (8) summary

PHA02682
Location:3007 → 3157

PHA02682; ORF080 virion core protein; Provisional

smart00041
Location:3339 → 3411

CT; C-terminal cystine knot-like domain (CTCK)

smart00216
Location:890 → 1049

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:622 → 692

C8; This domain contains 8 conserved cysteine residues

pfam05109
Location:2052 → 2254

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01826
Location:337 → 393

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:265 → 333

C8; C8 domain

pfam13330
Location:1605 → 1691

Mucin2_WxxW; Mucin-2 protein WxxW repeating region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

141342695..141372964

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508499.2 → XP_006508562.1 mucin-5AC isoform X1

UniProtKB/TrEMBL

E9QAQ8

Related

ENSMUSP00000122353.4, ENSMUST00000155534.9

Conserved Domains (8) summary

PHA02682
Location:3012 → 3162

PHA02682; ORF080 virion core protein; Provisional

smart00041
Location:3344 → 3416

CT; C-terminal cystine knot-like domain (CTCK)

smart00216
Location:895 → 1054

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:627 → 697

C8; This domain contains 8 conserved cysteine residues

pfam05109
Location:2057 → 2259

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01826
Location:341 → 397

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:269 → 337

C8; C8 domain

pfam13330
Location:1610 → 1696

Mucin2_WxxW; Mucin-2 protein WxxW repeating region
XM_006508500.2 → XP_006508563.1 mucin-5AC isoform X2

UniProtKB/TrEMBL

E9QAQ8

Related

ENSMUSP00000039699.8, ENSMUST00000041924.14

Conserved Domains (8) summary

PHA02682
Location:2980 → 3130

PHA02682; ORF080 virion core protein; Provisional

smart00041
Location:3312 → 3384

CT; C-terminal cystine knot-like domain (CTCK)

smart00216
Location:895 → 1054

VWD; von Willebrand factor (vWF) type D domain

smart00832
Location:627 → 697

C8; This domain contains 8 conserved cysteine residues

pfam05109
Location:1869 → 2227

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam01826
Location:341 → 397

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:269 → 337

C8; C8 domain

pfam13330
Location:1610 → 1696

Mucin2_WxxW; Mucin-2 protein WxxW repeating region