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    MEP1 ammonium permease MEP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEP1
    Official Full Name
    ammonium permease MEP1
    Primary source
    SGD:S000003353
    Locus tag
    YGR121C
    See related
    AllianceGenome:SGD:S000003353; FungiDB:YGR121C; VEuPathDB:YGR121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AMT1
    Summary
    Enables ammonium channel activity. Involved in ammonium transmembrane transport and nitrogen utilization. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MEP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (731449..732927, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Golgi transport complex subunit COG2 Neighboring gene tRNA-Asn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae. Marini AM, et al. EMBO J, 1994 Aug 1. PMID 8062822, Free PMC Article
    2. Three functional transporters for constitutive, diurnally regulated, and starvation-induced uptake of ammonium into Arabidopsis roots. Gazzarrini S, et al. Plant Cell, 1999 May. PMID 10330477, Free PMC Article
    3. Regulation of the high-affinity ammonium transporter (BnAMT1;2) in the leaves of Brassica napus by nitrogen status. Pearson JN, et al. Plant Mol Biol, 2002 Jul. PMID 12090624
    4. Dynamic copper(I) imaging in mammalian cells with a genetically encoded fluorescent copper(I) sensor. Wegner SV, et al. J Am Chem Soc, 2010 Mar 3. PMID 20131768
    5. Identification of the Zn(II) site in the copper-responsive yeast transcription factor, AMT1: a conserved Zn module. Farrell RA, et al. Biochemistry, 1996 Feb 6. PMID 8634288

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an ammonium permease MEP1-based sensing mechanism for rapid activation of the protein kinase A pathway
      Title: Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ammonium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ammonium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ammonium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ammonium transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ammonium permease MEP1
    NP_011636.3
    • Ammonium permease; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation; activity regulated by TORC1 effectors, Npr1p and Par32p; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      731449..732927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181250.3 → NP_011636.3  TPA: ammonium permease MEP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011636.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ2, P40260
      UniProtKB/TrEMBL
      A6ZUD4, B3LIA8, B5VJ67, C7GSX1, C8Z912, G2WEK3, N1P9W6
      Conserved Domains (1) summary
      TIGR00836
      Location:19 → 424
      amt; ammonium transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40260.1

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