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    Slc22a16 solute carrier family 22 (organic cation transporter), member 16 [ Mus musculus (house mouse) ]

    Gene ID: 70840, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a16provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 16provided by MGI
    Primary source
    MGI:MGI:1918090
    See related
    Ensembl:ENSMUSG00000019834 AllianceGenome:MGI:1918090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CT2; OCT6; OKB1; FLIPT2; 4921504E14Rik
    Summary
    Predicted to enable amine transmembrane transporter activity; carnitine transmembrane transporter activity; and spermidine transmembrane transporter activity. Predicted to be involved in several processes, including carnitine transmembrane transport; flagellated sperm motility; and spermidine transmembrane transport. Predicted to be located in cytosol and plasma membrane. Orthologous to human SLC22A16 (solute carrier family 22 member 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 66.4) See more
    Orthologs
    human all
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    Genomic context

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    See Slc22a16 in Genome Data Viewer
    Location:
    10 B1; 10 21.99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (40446317..40480128)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40570321..40604132)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26427 Neighboring gene small nuclear ribonucleoprotein B pseudogene Neighboring gene STARR-seq mESC enhancer starr_26428 Neighboring gene predicted gene, 17795 Neighboring gene D-aspartate oxidase Neighboring gene methyltransferase like 24 Neighboring gene STARR-seq mESC enhancer starr_26430 Neighboring gene STARR-seq mESC enhancer starr_26431 Neighboring gene STARR-seq mESC enhancer starr_26432 Neighboring gene STARR-seq mESC enhancer starr_26433

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Kellerer S, et al. Development, 2006 Aug. PMID 16790476
    2. Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon. Xu Q, et al. Development, 2005 Nov. PMID 16221724
    3. Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways. Schuurmans C, et al. EMBO J, 2004 Jul 21. PMID 15229646, Free PMC Article
    4. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Jepsen K, et al. Nature, 2007 Nov 15. PMID 17928865
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118295

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnitine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carnitine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables spermidine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spermidine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carnitine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carnitine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within carnitine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carnitine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22 member 16
    Names
    carnitine transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027572.1 → NP_081848.1  solute carrier family 22 member 16

      See identical proteins and their annotated locations for NP_081848.1

      Status: VALIDATED

      Source sequence(s)
      BC100473
      Consensus CDS
      CCDS23796.1
      UniProtKB/Swiss-Prot
      Q3LVC1, Q497L8
      UniProtKB/TrEMBL
      B2RRB7
      Related
      ENSMUSP00000077428.8, ENSMUST00000078314.14
      Conserved Domains (2) summary
      cd06174
      Location:163 → 525
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:14 → 535
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      40446317..40480128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512850.4 → XP_006512913.1  solute carrier family 22 member 16 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:18 → 365
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q497L8.1 GenPept UniProtKB/Swiss-Prot:Q497L8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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