Il36b interleukin 36B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il36bprovided by MGI
Official Full Name: interleukin 36Bprovided by MGI
Primary source: MGI:MGI:1916927
See related: Ensembl:ENSMUSG00000026985 AllianceGenome:MGI:1916927
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If36b; Il1f8; 2310043N20Rik
Summary: Enables cytokine activity. Acts upstream of or within positive regulation of T cell differentiation and positive regulation of interleukin-6 production. Located in extracellular space. Orthologous to human IL36B (interleukin 36 beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 16.21 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (24043184..24050115)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (24153172..24160103)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-36beta exacerbates DSS-induce acute colitis via inhibiting Foxp3(+) regulatory T cell response and increasing Th2 cell response.
Title: Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3(+) regulatory T cell response and increasing Th2 cell response.
Effect of Interleukin-36beta on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis.
Title: Effect of Interleukin-36β on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis.
Interleukin 36beta may enhance antitumor immune response of CD8(+)T cells by regulating GM16343.
Title: Long Noncoding RNA GM16343 Promotes IL-36β to Regulate Tumor Microenvironment by CD8(+)T cells.
IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin
Title: IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin.
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity
Title: Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity.
A critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses.
Title: IL-36R ligands are potent regulators of dendritic and T cells.
The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce any of the classical IL-1 responses in glial cells.
Title: The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of T cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-36 beta

Names: IL-1F8; interleukin 1 family, member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027163.4 → NP_081439.1 interleukin-36 beta

See identical proteins and their annotated locations for NP_081439.1

Status: PROVISIONAL

Source sequence(s)

BC119517

Consensus CDS

CCDS38063.1

UniProtKB/Swiss-Prot

Q8R461, Q9D6Z6

UniProtKB/TrEMBL

Q08EA6

Related

ENSMUSP00000028363.2, ENSMUST00000028363.2

Conserved Domains (1) summary

cl00094
Location:37 → 180

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).