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    Drc7 dynein regulatory complex subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 330830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drc7provided by MGI
    Official Full Name
    dynein regulatory complex subunit 7provided by MGI
    Primary source
    MGI:MGI:2685616
    See related
    Ensembl:ENSMUSG00000031786 AllianceGenome:MGI:2685616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm770; SRG-L; SRG-S; Ccdc135
    Summary
    Involved in sperm axoneme assembly. Predicted to be located in cytoplasm. Predicted to be active in motile cilium. Is expressed in lateral ventricle choroid plexus; metencephalon floor plate; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human DRC7 (dynein regulatory complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 20.5), lung adult (RPKM 3.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Drc7 in Genome Data Viewer
    Location:
    8 C5; 8 47.12 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95781731..95804769)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95055103..95078141)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97500803-97501004 Neighboring gene predicted gene, 30968 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97604749-97604932 Neighboring gene katanin p80 (WD40-containing) subunit B 1 Neighboring gene kinesin family member C3 Neighboring gene predicted gene, 31224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells. Ma Q, et al. Mol Reprod Dev, 2006 Sep. PMID 16804880
    2. Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice. Morohoshi A, et al. PLoS Genet, 2020 Jan. PMID 31961863, Free PMC Article
    3. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Castaneda JM, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630322, Free PMC Article
    4. Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Bachvarova V, et al. Matrix Biol, 2020 Nov. PMID 32201365
    5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drc7 KO male mice were infertile due to their short immotile spermatozoa. Drc7 is essential for the correct assembly of the N-DRC and flagella.
      Title: Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.
    2. Gm770 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
      Title: Tissue expression patterns identify mouse cilia genes.
    3. SRG-L (Spermatogenesis Related Gene expressed in late stages of spermatogenic cells) may play definite roles regulating differentiation of germ cells during spermatogenesis, particularly during meiosis and spermiogenesis
      Title: Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex subunit 7
    Names
    coiled-coil domain containing 135
    coiled-coil domain-containing protein 135
    coiled-coil domain-containing protein lobo homolog
    spermatogenesis-related gene in late stages of spermatogenesis cells protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042715.3 → NP_001036180.2  dynein regulatory complex subunit 7

      See identical proteins and their annotated locations for NP_001036180.2

      Status: VALIDATED

      Source sequence(s)
      AC103935
      Consensus CDS
      CCDS40444.1
      UniProtKB/Swiss-Prot
      G3X9B0, Q148T2, Q6V3W6
      Related
      ENSMUSP00000053972.7, ENSMUST00000058479.7
      Conserved Domains (2) summary
      PRK10246
      Location:688 → 851
      PRK10246; exonuclease subunit SbcC; Provisional
      pfam01841
      Location:174 → 215
      Transglut_core; Transglutaminase-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95781731..95804769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531132.3 → XP_006531195.1  dynein regulatory complex subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006531195.1

      UniProtKB/Swiss-Prot
      G3X9B0, Q148T2, Q6V3W6
      Conserved Domains (2) summary
      PRK10246
      Location:688 → 851
      PRK10246; exonuclease subunit SbcC; Provisional
      pfam01841
      Location:174 → 215
      Transglut_core; Transglutaminase-like superfamily

    RNA

    1. XR_003947312.1 RNA Sequence

    2. XR_003947311.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6V3W6.4 GenPept UniProtKB/Swiss-Prot:Q6V3W6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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