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    Stk36 serine/threonine kinase 36 [ Mus musculus (house mouse) ]

    Gene ID: 269209, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stk36provided by MGI
    Official Full Name
    serine/threonine kinase 36provided by MGI
    Primary source
    MGI:MGI:1920831
    See related
    Ensembl:ENSMUSG00000033276 AllianceGenome:MGI:1920831
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FU; Fused; mKIAA1278; B930045J24; 1700112N14Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Involved in several processes, including cilium assembly; positive regulation of smoothened signaling pathway; and smoothened signaling pathway. Acts upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Located in cytoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; tail somite; and testis. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 49.4), whole brain E14.5 (RPKM 6.3) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stk36 in Genome Data Viewer
    Location:
    1 C4; 1 38.54 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74640583..74676053)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74601391..74636894)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E791 Neighboring gene BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Neighboring gene ring finger protein 25 Neighboring gene STARR-seq mESC enhancer starr_01341 Neighboring gene tubulin tyrosine ligase-like family, member 4 Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1278, MGC58023

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase 36
    Names
    fused homolog
    serine/threonine kinase 36 (fused homolog, Drosophila)
    NP_001391006.1
    NP_001391007.1
    NP_778196.2
    XP_036021382.1
    XP_036021383.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404077.1NP_001391006.1  serine/threonine-protein kinase 36 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117610
    2. NM_001404078.1NP_001391007.1  serine/threonine-protein kinase 36 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Related
      ENSMUSP00000084433.5, ENSMUST00000087186.11
    3. NM_175031.4NP_778196.2  serine/threonine-protein kinase 36 isoform 1

      See identical proteins and their annotated locations for NP_778196.2

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Consensus CDS
      CCDS35619.1
      UniProtKB/Swiss-Prot
      Q69ZM6, Q6PDI0, Q80XQ6
      Related
      ENSMUSP00000084430.5, ENSMUST00000087183.11
      Conserved Domains (2) summary
      smart00220
      Location:4254
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14002
      Location:2254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36

    RNA

    1. NR_175802.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610
    2. NR_175803.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610
      Related
      ENSMUST00000145673.8
    3. NR_175804.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610
    4. NR_175805.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC117610

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74640583..74676053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165489.1XP_036021382.1  serine/threonine-protein kinase 36 isoform X2

      Conserved Domains (1) summary
      cd14002
      Location:2254
      STKc_STK36; Catalytic domain of Serine/Threonine Kinase 36
    2. XM_036165490.1XP_036021383.1  serine/threonine-protein kinase 36 isoform X3

      Conserved Domains (4) summary
      COG1413
      Location:9071152
      HEAT; HEAT repeat [General function prediction only]
      sd00044
      Location:962989
      HEAT; HEAT repeat [structural motif]
      pfam13646
      Location:10281123
      HEAT_2; HEAT repeats
      cl21453
      Location:10118
      PKc_like; Protein Kinases, catalytic domain