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    Serpinb5 serine (or cysteine) peptidase inhibitor, clade B, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 20724, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpinb5provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 5provided by MGI
    Primary source
    MGI:MGI:109579
    See related
    Ensembl:ENSMUSG00000067006 AllianceGenome:MGI:109579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI-5; Spi7; Maspin; ovalbumin; 1110036M19Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Located in sarcoplasm. Is active in cornified envelope. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SERPINB5 (serpin family B member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 5.5), colon adult (RPKM 2.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Serpinb5 in Genome Data Viewer
    Location:
    1 E2.1; 1 50.34 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (106788905..106811078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (106861175..106883348)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene STARR-positive B cell enhancer ABC_E4341 Neighboring gene vacuolar protein sorting 4B Neighboring gene STARR-positive B cell enhancer ABC_E3296 Neighboring gene predicted gene, 53577 Neighboring gene STARR-positive B cell enhancer ABC_E10027 Neighboring gene STARR-seq mESC enhancer starr_01863 Neighboring gene STARR-seq mESC enhancer starr_01864 Neighboring gene POU domain, class 2, transcription factor 3, related sequence 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serpin B5
    Names
    peptidase inhibitor 5
    protease inhibitor 5
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5
    serine (or cysteine) proteinase inhibitor, clade B, member 5
    serine protease inhibitor 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360853.1NP_001347782.1  serpin B5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC025047, AC163626, AK136532, U54705
      Consensus CDS
      CCDS35684.1
      UniProtKB/Swiss-Prot
      P70124, Q3ULZ0
      Related
      ENSMUSP00000108350.2, ENSMUST00000112730.8
      Conserved Domains (1) summary
      cd02057
      Location:4375
      maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...
    2. NM_001360854.1NP_001347783.1  serpin B5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC025047, AC163626
      Conserved Domains (1) summary
      cl00137
      Location:1204
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    3. NM_009257.4NP_033283.1  serpin B5 isoform a

      See identical proteins and their annotated locations for NP_033283.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC025047, AC163626, AK136532
      Consensus CDS
      CCDS35684.1
      UniProtKB/Swiss-Prot
      P70124, Q3ULZ0
      Related
      ENSMUSP00000083908.7, ENSMUST00000086701.13
      Conserved Domains (1) summary
      cd02057
      Location:4375
      maspin_like; Maspin (mammary serine proteinase inhibitor), a member of the serpin superfamily, with a multitude of effects on cells and tissues at an assortment of developmental stages. Maspin has tumor suppressing activity against breast and prostate cancer. In ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      106788905..106811078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)