U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Prkcz protein kinase C, zeta [ Mus musculus (house mouse) ]

    Gene ID: 18762, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prkczprovided by MGI
    Official Full Name
    protein kinase C, zetaprovided by MGI
    Primary source
    MGI:MGI:97602
    See related
    Ensembl:ENSMUSG00000029053 AllianceGenome:MGI:97602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pkcz; zetaPKC; aPKCzeta; nPKC-zeta
    Summary
    Enables protein serine/threonine kinase activity. Involved in positive regulation of T-helper 2 cell differentiation and positive regulation of cytokine production. Acts upstream of or within several processes, including neuron projection extension; protein localization to plasma membrane; and protein phosphorylation. Located in several cellular components, including axon hillock; myelin sheath abaxonal region; and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cortex adult (RPKM 34.2), cerebellum adult (RPKM 31.5) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Prkcz in Genome Data Viewer
    Location:
    4 E2; 4 86.17 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155344579..155445856, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155260118..155361428, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6296 Neighboring gene predicted gene, 33187 Neighboring gene Fanconi anemia core complex associated protein 20 Neighboring gene STARR-seq mESC enhancer starr_12256 Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit delta Neighboring gene cilia and flagella associated protein 74

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol-dependent serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic potentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within microtubule cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuron projection extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T-helper 2 cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T-helper 2 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-13 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-5 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon hillock IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell leading edge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in myelin sheath abaxonal region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein kinase C zeta type
    Names
    atypical protein kinase C
    protein kinase C zeta subspecies
    NP_001034168.1
    NP_001342107.1
    NP_001411727.1
    NP_001411728.1
    NP_001411729.1
    NP_001411730.1
    NP_001411731.1
    NP_001411732.1
    NP_001411733.1
    NP_032886.2
    XP_006538719.1
    XP_017175531.1
    XP_030109177.1
    XP_036019727.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039079.3NP_001034168.1  protein kinase C zeta type isoform b

      See identical proteins and their annotated locations for NP_001034168.1

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
      Consensus CDS
      CCDS19027.1
      UniProtKB/TrEMBL
      Q3V341
      Related
      ENSMUSP00000099467.5, ENSMUST00000103178.11
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001355178.2NP_001342107.1  protein kinase C zeta type isoform c

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
      UniProtKB/TrEMBL
      A4QPC7
      Conserved Domains (2) summary
      pfam00130
      Location:2373
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:128484
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001424798.1NP_001411727.1  protein kinase C zeta type isoform d

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
      UniProtKB/TrEMBL
      A4QPC7
    4. NM_001424799.1NP_001411728.1  protein kinase C zeta type isoform e

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
      UniProtKB/TrEMBL
      A4QPC7
    5. NM_001424800.1NP_001411729.1  protein kinase C zeta type isoform f

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
      UniProtKB/TrEMBL
      A4QPC7
    6. NM_001424801.1NP_001411730.1  protein kinase C zeta type isoform g

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
    7. NM_001424802.1NP_001411731.1  protein kinase C zeta type isoform h

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
    8. NM_001424803.1NP_001411732.1  protein kinase C zeta type isoform i

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
    9. NM_001424804.1NP_001411733.1  protein kinase C zeta type isoform j

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
    10. NM_008860.4NP_032886.2  protein kinase C zeta type isoform a

      See identical proteins and their annotated locations for NP_032886.2

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413
      Consensus CDS
      CCDS19026.1
      UniProtKB/Swiss-Prot
      A2AD76, Q02956, Q3UHM5, Q7TST7
      UniProtKB/TrEMBL
      A4QPC7
      Related
      ENSMUSP00000030922.8, ENSMUST00000030922.15
      Conserved Domains (4) summary
      cd06404
      Location:1698
      PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
      smart00220
      Location:252518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00130
      Location:131183
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl21453
      Location:236592
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_188944.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL670227, AL670413

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      155344579..155445856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538656.4XP_006538719.1  protein kinase C zeta type isoform X2

      See identical proteins and their annotated locations for XP_006538719.1

      UniProtKB/TrEMBL
      Q3V341
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036163834.1XP_036019727.1  protein kinase C zeta type isoform X2

      UniProtKB/TrEMBL
      Q3V341
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    3. XM_030253317.1XP_030109177.1  protein kinase C zeta type isoform X2

      UniProtKB/TrEMBL
      Q3V341
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain
    4. XM_017320042.3XP_017175531.1  protein kinase C zeta type isoform X2

      UniProtKB/TrEMBL
      Q3V341
      Conserved Domains (1) summary
      cl21453
      Location:53409
      PKc_like; Protein Kinases, catalytic domain