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    Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 18739, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pitpnm1provided by MGI
    Official Full Name
    phosphatidylinositol transfer protein, membrane-associated 1provided by MGI
    Primary source
    MGI:MGI:1197524
    See related
    Ensembl:ENSMUSG00000024851 AllianceGenome:MGI:1197524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rd9; RdgB; DRES9; Mpt-1; Nir-2; RdgB1; Pitpnm; PITPnm 1
    Summary
    Predicted to enable several functions, including phospholipid binding activity; phospholipid transporter activity; and receptor tyrosine kinase binding activity. Predicted to be involved in phospholipid transport. Predicted to be located in cell body; cytosol; and intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and sensory organ. Orthologous to human PITPNM1 (phosphatidylinositol transfer protein membrane associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 64.7), spleen adult (RPKM 49.4) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pitpnm1 in Genome Data Viewer
    Location:
    19 A; 19 3.81 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4150012..4163966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4099998..4113966)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E84 Neighboring gene cyclin dependent kinase 2 associated protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4103876-4104077 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1965 Neighboring gene STARR-positive B cell enhancer ABC_E1966 Neighboring gene transmembrane protein 134 Neighboring gene STARR-positive B cell enhancer ABC_E5674 Neighboring gene calcium binding protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    membrane-associated phosphatidylinositol transfer protein 1
    Names
    drosophila retinal degeneration B homolog 1
    pyk2 N-terminal domain-interacting receptor 2
    retinal degeneration 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008851.4NP_032877.1  membrane-associated phosphatidylinositol transfer protein 1

      See identical proteins and their annotated locations for NP_032877.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AC109138, BC048150, BY261372, CJ097166
      Consensus CDS
      CCDS37883.1
      UniProtKB/Swiss-Prot
      O35954
      Related
      ENSMUSP00000097599.4, ENSMUST00000100022.4
      Conserved Domains (4) summary
      cd08889
      Location:1257
      SRPBCC_PITPNM1-2_like; Lipid-binding SRPBCC domain of mammalian PITPNM1-2 and related proteins (Class IIA PITPs)
      smart00775
      Location:10221153
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:688878
      DDHD; DDHD domain
      cl21470
      Location:963995
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

    RNA

    1. NR_075078.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 5' exon structure compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC109138
    2. NR_177186.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109138
    3. NR_177187.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109138

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4150012..4163966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250773.2XP_030106633.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X2

      Related
      ENSMUST00000151957.8
      Conserved Domains (3) summary
      smart00775
      Location:425556
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:91281
      DDHD; DDHD domain
      cl21470
      Location:346430
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    2. XM_036161462.1XP_036017355.1  membrane-associated phosphatidylinositol transfer protein 1 isoform X1

      Conserved Domains (2) summary
      smart00775
      Location:429560
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:95285
      DDHD; DDHD domain

    RNA

    1. XR_003952754.2 RNA Sequence

    2. XR_003952755.2 RNA Sequence

    3. XR_004940120.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001136078.1: Suppressed sequence

      Description
      NM_001136078.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.