Mrgpra1 MAS-related GPR, member A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrgpra1provided by MGI
Official Full Name: MAS-related GPR, member A1provided by MGI
Primary source: MGI:MGI:3033095
See related: Ensembl:ENSMUSG00000050650 AllianceGenome:MGI:3033095
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MrgA1
Summary: Enables neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Orthologous to human MRGPRX3 (MAS related GPR family member X3) and MRGPRX4 (MAS related GPR family member X4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 B3; 7 30.8 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46984623..47003988, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (47334875..47354240, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We deduce that substance P activates MrgprA1 on sensory neurons rather than NK-1R to induce itch
Title: Substance P activates Mas-related G protein-coupled receptors to induce itch.
is activated by RF-amide-related peptides through the Galpha q/11 pathway
Title: Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489525

NoName (e-PCR)
- UniSTS:237375

AI843275 (e-PCR)
- UniSTS:165958

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member A1

Names: RF-amide G protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153095.2 → NP_694735.2 mas-related G-protein coupled receptor member A1

See identical proteins and their annotated locations for NP_694735.2

Status: VALIDATED

Source sequence(s)

AC163020, AY042191

Consensus CDS

CCDS21295.2

UniProtKB/TrEMBL

G3UW97, W8W3M1

Related

ENSMUSP00000129978.2, ENSMUST00000098438.4

Conserved Domains (2) summary

pfam00001
Location:57 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl23747
Location:194 → 295

UPF0182; uncharacterized protein family (UPF0182)