Trarg1 trafficking regulator of GLUT4 (SLC2A4) 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trarg1provided by MGI
Official Full Name: trafficking regulator of GLUT4 (SLC2A4) 1provided by MGI
Primary source: MGI:MGI:3029307
See related: Ensembl:ENSMUSG00000046275 AllianceGenome:MGI:3029307
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DSPB1; Lost1; Tusc5; C130069F04Rik
Summary: Involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Acts upstream of or within establishment of localization in cell and vesicle fusion to plasma membrane. Located in cytoplasmic vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; sensory organ; and white fat. Orthologous to human TRARG1 (trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 33.0), genital fat pad adult (RPKM 17.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.98 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (76570699..76589490)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76679873..76698664)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study uses a combination of bioinformatics prediction tools and biochemical assays to define the membrane topology of the 173-amino acid mouse TRARG1. These analyses revealed that, contrary to the consensus prediction, the N-terminus is cytosolic and that a short segment at the C-terminus resides in the luminal/extracellular space.
Title: Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1).
These findings may point to participation of Tusc5 in shared adipose-nervous system functions.
Title: Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to plasma membrane protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within endosome to plasma membrane protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose import in response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose import in response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vesicle fusion to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trafficking regulator of GLUT4 1

Names: dispanin subfamily B member 1; tumor suppressor candidate 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.