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    Plin5 perilipin 5 [ Mus musculus (house mouse) ]

    Gene ID: 66968, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plin5provided by MGI
    Official Full Name
    perilipin 5provided by MGI
    Primary source
    MGI:MGI:1914218
    See related
    Ensembl:ENSMUSG00000011305 AllianceGenome:MGI:1914218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLDP; Lsdp5; PAT-1; 2310076L09Rik
    Summary
    Enables identical protein binding activity and lipase binding activity. Involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of sequestering of triglyceride; and regulation of lipid metabolic process. Located in cytosol. Colocalizes with lipid droplet. Is expressed in brown fat. Orthologous to human PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 44.7), adrenal adult (RPKM 29.0) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plin5 in Genome Data Viewer
    Location:
    17 D; 17 29.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56418601..56424606, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56111597..56117606, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 4 Neighboring gene leucine-rich alpha-2-glycoprotein 1 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Atorvastatin reduces lipid accumulation in the liver by activating protein kinase A-mediated phosphorylation of perilipin 5. Gao X, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2017 Dec. PMID 28919478
    2. Deletion of Perilipin 5 Protects Against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation. Asimakopoulou A, et al. Cells, 2020 May 28. PMID 32481590, Free PMC Article
    3. Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier. Pollak NM, et al. J Lipid Res, 2013 Apr. PMID 23345410, Free PMC Article
    4. Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress. Wang C, et al. Free Radic Biol Med, 2019 Sep. PMID 31291602
    5. Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice. Kolleritsch S, et al. Cardiovasc Res, 2020 Feb 1. PMID 31166588, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The influence of perilipin 5 deficiency on gut microbiome profiles in murine metabolic dysfunction-associated fatty liver disease (MAFLD) and MAFLD-hepatocellular carcinoma.
      Title: The influence of perilipin 5 deficiency on gut microbiome profiles in murine metabolic dysfunction-associated fatty liver disease (MAFLD) and MAFLD-hepatocellular carcinoma.
    2. PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-kappaB Axis.
      Title: PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-κB Axis.
    3. Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control.
      Title: Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control.
    4. Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease.
      Title: Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease.
    5. Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice.
      Title: Perilipin 5 protects the mitochondrial oxidative functions and improves the alcoholic liver injury in mice.
    6. Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
      Title: Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice.
    7. PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
      Title: PLIN5 interacts with FATP4 at membrane contact sites to promote lipid droplet-to-mitochondria fatty acid transport.
    8. Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
      Title: Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.
    9. Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1alpha following vascular injury.
      Title: Plin5 inhibits proliferation and migration of vascular smooth muscle cell through interacting with PGC-1α following vascular injury.
    10. Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3beta-Nrf2 pathway.
      Title: Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (56)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (10)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lipase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of sequestering of triglyceride IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of triglyceride biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of triglyceride biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    perilipin-5
    Names
    lipid droplet associated protein
    lipid droplet-associated protein PAT-1
    lipid storage droplet protein 5
    myocardial LD protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077348.1 → NP_001070816.1  perilipin-5

      See identical proteins and their annotated locations for NP_001070816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.
      Source sequence(s)
      AY919875, CT009719, DQ473305
      Consensus CDS
      CCDS37662.1
      UniProtKB/Swiss-Prot
      Q78IK8, Q8BVZ1
      Related
      ENSMUSP00000108695.3, ENSMUST00000113072.3
      Conserved Domains (1) summary
      pfam03036
      Location:31 → 383
      Perilipin; Perilipin family

    2. NM_025874.3 → NP_080150.2  perilipin-5

      See identical proteins and their annotated locations for NP_080150.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BY101690, DQ473305
      Consensus CDS
      CCDS37662.1
      UniProtKB/Swiss-Prot
      Q78IK8, Q8BVZ1
      Related
      ENSMUSP00000019808.6, ENSMUST00000019808.12
      Conserved Domains (1) summary
      pfam03036
      Location:31 → 383
      Perilipin; Perilipin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56418601..56424606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524805.2 → XP_006524868.1  perilipin-5 isoform X1

      Conserved Domains (1) summary
      pfam03036
      Location:33 → 381
      Perilipin; Perilipin family

    2. XM_017317614.2 → XP_017173103.1  perilipin-5 isoform X2

      Conserved Domains (1) summary
      pfam03036
      Location:3 → 255
      Perilipin; Perilipin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVZ1.1 GenPept UniProtKB/Swiss-Prot:Q8BVZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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