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    Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 [ Mus musculus (house mouse) ]

    Gene ID: 68198, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ndufb2provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B2provided by MGI
    Primary source
    MGI:MGI:1915448
    See related
    Ensembl:ENSMUSG00000002416 AllianceGenome:MGI:1915448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8kDa; AGGG; CI-AGGG; 1810011O01Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including axial skeleton; brown fat; cranium; ear; and limb. Orthologous to human NDUFB2 (NADH:ubiquinone oxidoreductase subunit B2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 286.4), duodenum adult (RPKM 227.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufb2 in Genome Data Viewer
    Location:
    6 B1; 6 18.42 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39569499..39576777)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39592565..39599843)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene aarF domain containing kinase 2 Neighboring gene Braf transforming gene Neighboring gene predicted gene, 34389 Neighboring gene ferritin heavy chain, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article
    2. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Yao Y, et al. Nat Commun, 2020 Jul 30. PMID 32732898, Free PMC Article
    3. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article
    4. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788
    5. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2
    NADH-ubiquinone oxidoreductase AGGG subunit
    complex I-AGGG
    NP_001345726.1
    NP_080888.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358797.1 → NP_001345726.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AC122345, AK028334
      Consensus CDS
      CCDS20025.1
      UniProtKB/Swiss-Prot
      Q9CPU2
      Related
      ENSMUSP00000118918.2, ENSMUST00000135671.8
      Conserved Domains (1) summary
      pfam14813
      Location:37 → 104
      NADH_B2; NADH dehydrogenase 1 beta subcomplex subunit 2

    2. NM_026612.4 → NP_080888.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080888.1

      Status: VALIDATED

      Source sequence(s)
      AC122345, AK019008, CF533247
      Consensus CDS
      CCDS20025.1
      UniProtKB/Swiss-Prot
      Q9CPU2
      Related
      ENSMUSP00000114095.2, ENSMUST00000119379.2
      Conserved Domains (1) summary
      pfam14813
      Location:37 → 104
      NADH_B2; NADH dehydrogenase 1 beta subcomplex subunit 2

    RNA

    1. NR_152450.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122345, AI391300, CF533247

    2. NR_152451.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122345

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39569499..39576777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPU2.1 GenPept UniProtKB/Swiss-Prot:Q9CPU2

    Gene LinkOut

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