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    bioF 8-amino-7-oxononanoate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945384, updated on 3-Dec-2024

    Summary

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    Official Symbol
    bioF
    Official Full Name
    8-amino-7-oxononanoate synthase
    Primary source
    ECOCYC:EG10121
    Locus tag
    b0776
    See related
    ASAP:ABE-0002646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0765
    Summary
    8-Amino-7-oxononanoate synthase catalyzes the first committed step in biotin biosynthesis, the decarboxylative condensation of L-alanine and 6-carboxyhexanoyl-CoA . [More information is available at EcoCyc: EG10121].
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    Genomic context

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    Sequence:
    NC_000913.3 (810381..811535)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative kinase inhibitor Neighboring gene adenosylmethionine-8-amino-7-oxononanoate aminotransferase Neighboring gene biotin synthase Neighboring gene malonyl-acyl carrier protein methyltransferase Neighboring gene dethiobiotin synthetase Neighboring gene UvrABC excision nuclease subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An early intermediate in the biosynthesis of biotin: Incorporation studies with [1,7-C(2)]pimelic acid. Eisenberg MA, et al. Biochem J, 1966 Dec. PMID 16742432, Free PMC Article
    2. Preparation of pimeloyl-coenzyme A. Eisenberg MA. Methods Enzymol, 1979. PMID 440115
    3. Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies. Webster SP, et al. Biochemistry, 2000 Jan 25. PMID 10642176
    4. Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine. Alexeev D, et al. Org Biomol Chem, 2006 Apr 7. PMID 16557306
    5. Functional asymmetry for the active sites of linked 5-aminolevulinate synthase and 8-amino-7-oxononanoate synthase. Turbeville TD, et al. Arch Biochem Biophys, 2011 Jul. PMID 21600186, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 8-amino-7-oxononanoate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-amino-7-oxononanoate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 8-amino-7-oxononanoate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    8-amino-7-oxononanoate synthase
    NP_415297.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      810381..811535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415297.1 8-amino-7-oxononanoate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415297.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZR45
      Conserved Domains (1) summary
      PRK05958
      Location:1 → 382
      PRK05958; 8-amino-7-oxononanoate synthase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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