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    Pgpep1 pyroglutamyl-peptidase I [ Mus musculus (house mouse) ]

    Gene ID: 66522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgpep1provided by MGI
    Official Full Name
    pyroglutamyl-peptidase Iprovided by MGI
    Primary source
    MGI:MGI:1913772
    See related
    Ensembl:ENSMUSG00000056204 AllianceGenome:MGI:1913772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGP; Pcp; PGPI; PAP-I; PGP-I; Gm19458; 2810003H13Rik
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol. Is expressed in central nervous system; genitourinary system; gut; lung; and submandibular gland primordium. Orthologous to human PGPEP1 (pyroglutamyl-peptidase I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 36.5), adrenal adult (RPKM 16.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pgpep1 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.15 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71099086..71113096, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70646436..70660446, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6645 Neighboring gene STARR-seq mESC enhancer starr_21778 Neighboring gene growth differentiation factor 15 Neighboring gene predicted gene, 34154 Neighboring gene STARR-seq mESC enhancer starr_21782 Neighboring gene STARR-positive B cell enhancer ABC_E10505 Neighboring gene STARR-positive B cell enhancer ABC_E6646 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73197019-73197273 Neighboring gene LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene predicted gene, 39191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme. Dando PM, et al. Protein Expr Purif, 2003 Mar. PMID 12651114
    2. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning and sequencing of the mouse (AJ278829) pyroglutamyl-peptidase I
      Title: Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables pyroglutamyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pyroglutamyl-peptidase 1
    Names
    5-oxoprolyl-peptidase
    putative pyroglutamyl-peptidase I
    pyroglutamyl aminopeptidase I
    pyrrolidone-carboxylate peptidase
    NP_075706.1
    XP_006509782.1
    XP_030099578.1
    XP_030099579.1
    XP_030099580.1
    XP_030099581.1
    XP_030099582.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023217.4 → NP_075706.1  pyroglutamyl-peptidase 1

      See identical proteins and their annotated locations for NP_075706.1

      Status: VALIDATED

      Source sequence(s)
      AC157774, AC166931, BC051938, BY313315
      Consensus CDS
      CCDS22377.1
      UniProtKB/Swiss-Prot
      Q9ESW8
      Related
      ENSMUSP00000070778.8, ENSMUST00000070173.9
      Conserved Domains (1) summary
      cd00501
      Location:6 → 199
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71099086..71113096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243719.1 → XP_030099579.1  pyroglutamyl-peptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSC4
      Conserved Domains (1) summary
      cl00237
      Location:1 → 122
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    2. XM_030243722.2 → XP_030099582.1  pyroglutamyl-peptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSC4
      Conserved Domains (1) summary
      cl00237
      Location:1 → 122
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    3. XM_006509719.5 → XP_006509782.1  pyroglutamyl-peptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006509782.1

      Conserved Domains (1) summary
      cd00501
      Location:6 → 160
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    4. XM_030243718.2 → XP_030099578.1  pyroglutamyl-peptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSC4
      Conserved Domains (1) summary
      cl00237
      Location:1 → 122
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    5. XM_030243721.2 → XP_030099581.1  pyroglutamyl-peptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSC4
      Conserved Domains (1) summary
      cl00237
      Location:1 → 122
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...

    6. XM_030243720.2 → XP_030099580.1  pyroglutamyl-peptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GSC4
      Related
      ENSMUSP00000147879.2, ENSMUST00000210307.2
      Conserved Domains (1) summary
      cl00237
      Location:1 → 122
      Peptidase_C15; Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESW8.1 GenPept UniProtKB/Swiss-Prot:Q9ESW8

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