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    CBS cystathionine beta-synthase [ Homo sapiens (human) ]

    Gene ID: 875, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CBSprovided by HGNC
    Official Full Name
    cystathionine beta-synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:1550
    See related
    Ensembl:ENSG00000160200 MIM:613381; AllianceGenome:HGNC:1550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CBSL; HIP4
    Summary
    The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in liver (RPKM 30.2), brain (RPKM 11.6) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CBS in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43053191..43076873, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41444310..41468059, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44473301..44496983, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:44387630-44388130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44391589-44392348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13358 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:44395471-44396197 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44401218-44401758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44401759-44402300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44402301-44402840 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:44408954-44409120 Neighboring gene PBX/knotted 1 homeobox 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44412569-44413092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:44482429-44482929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44489293-44489916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44489917-44490540 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:44500286-44500457 Neighboring gene Sharpr-MPRA regulatory region 958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44506453-44507245 Neighboring gene uncharacterized LOC101928369 Neighboring gene U2 small nuclear RNA auxiliary factor 1 Neighboring gene mitochondrial ribosomal protein L51 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of cystathionine beta-synthase is downregulated in hepatocellular carcinoma and associated with poor prognosis. Kim J, et al. Oncol Rep, 2009 Jun. PMID 19424622
    2. Identification and functional analyses of CBS alleles in Spanish and Argentinian homocystinuric patients. Cozar M, et al. Hum Mutat, 2011 Jul. PMID 21520339
    3. Clinical and molecular findings of 13 families from Saudi Arabia and a family from Sudan with homocystinuria. Zaidi SH, et al. Clin Genet, 2012 Jun. PMID 21517828
    4. Gain-of-function polymorphisms of cystathionine β-synthase and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. Grobelny BT, et al. J Neurosurg, 2011 Jul. PMID 21417705
    5. Novel alleles of 31-bp VNTR polymorphism in the human cystathionine β-synthase (CBS) gene were detected in healthy Asians. Gan YY, et al. J Genet, 2010 Dec. PMID 21273695

    See all (448) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cystathionine-beta-synthase expression correlates with tumour progression and adverse prognosis in patients with colon cancer.
      Title: Cystathionine-β-synthase expression correlates with tumour progression and adverse prognosis in patients with colon cancer.
    2. Cellular turnover and degradation of the most common missense cystathionine beta-synthase variants causing homocystinuria.
      Title: Cellular turnover and degradation of the most common missense cystathionine beta-synthase variants causing homocystinuria.
    3. Biochemical and structural impact of two novel missense mutations in cystathionine beta-synthase gene associated with homocystinuria.
      Title: Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria.
    4. Architecture and regulation of filamentous human cystathionine beta-synthase.
      Title: Architecture and regulation of filamentous human cystathionine beta-synthase.
    5. Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis.
      Title: Association between CBS gene T833C, G919A and 844ins68 polymorphisms in the 8th exon region and coronary artery disease: a meta-analysis.
    6. [Exploration of cystathionine beta-synthase and cystathionine gamma-lyase gene expression poor prognostic predictive value with the application of bioinformatics data mining in liver cancer].
      Title: [Exploration of cystathionine β-synthase and cystathionine γ-lyase gene expression poor prognostic predictive value with the application of bioinformatics data mining in liver cancer].
    7. Disease-causing cystathionine beta-synthase linker mutations impair allosteric regulation.
      Title: Disease-causing cystathionine β-synthase linker mutations impair allosteric regulation.
    8. The Role of Cystathionine-beta-Synthase, H2S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies.
      Title: The Role of Cystathionine-β-Synthase, H(2)S, and miRNA-377 in Hypoxic-Ischemic Encephalopathy: Insights from Human and Animal Studies.
    9. ERalpha/ERbeta-directed CBS transcription mediates E2beta-stimulated hUAEC H2S production.
      Title: ERα/ERβ-directed CBS transcription mediates E2β-stimulated hUAEC H2S production.
    10. Understanding the role of R266K mutation in cystathionine beta-synthase (CBS) enzyme: an in silico study.
      Title: Understanding the role of R266K mutation in cystathionine β-synthase (CBS) enzyme: an in silico study.
    Submit: New GeneRIF Correction See all GeneRIFs (216)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Classic homocystinuria
    MedGen: C0751202 OMIM: 236200 GeneReviews: Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency
    		not available

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
    EBI GWAS Catalog
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    EBI GWAS Catalog
    Genome-wide association study of selenium concentrations.
    EBI GWAS Catalog
    Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
    EBI GWAS Catalog
    Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbon monoxide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cystathionine beta-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cystathionine beta-synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables heme binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables heme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables modified amino acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nitric oxide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nitrite reductase (NO-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA protection IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-cysteine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-serine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cartilage development involved in endochondral bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebellum morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endochondral ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homocysteine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in homocysteine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hydrogen sulfide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hydrogen sulfide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of nitric oxide mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to folic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cystathionine beta-synthase
    Names
    Cystathionine beta-synthase-like protein
    beta-thionase
    methylcysteine synthase
    serine sulfhydrase
    NP_000062.1
    NP_001171479.1
    NP_001171480.1
    NP_001307227.1
    NP_001308001.1
    XP_011528076.1
    XP_011528079.1
    XP_011528085.1
    XP_016883980.1
    XP_047296973.1
    XP_047296974.1
    XP_047296975.1
    XP_047296976.1
    XP_047296977.1
    XP_047296978.1
    XP_047296979.1
    XP_047296980.1
    XP_047296981.1
    XP_047296982.1
    XP_047296983.1
    XP_047296984.1
    XP_047296985.1
    XP_047296986.1
    XP_047296987.1
    XP_047296988.1
    XP_047296989.1
    XP_054180885.1
    XP_054180886.1
    XP_054180887.1
    XP_054180888.1
    XP_054180889.1
    XP_054180890.1
    XP_054180891.1
    XP_054180892.1
    XP_054180893.1
    XP_054180894.1
    XP_054180895.1
    XP_054180896.1
    XP_054180897.1
    XP_054180898.1
    XP_054180899.1
    XP_054180900.1
    XP_054180901.1
    XP_054180902.1
    XP_054180903.1
    XP_054180904.1
    XP_054180905.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008938.1 RefSeqGene

      Range
      4569..27740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_777

    mRNA and Protein(s)

    1. NM_000071.3 → NP_000062.1  cystathionine beta-synthase isoform 1

      See identical proteins and their annotated locations for NP_000062.1

      Status: REVIEWED

      Source sequence(s)
      AL137314, BC000440, DC300040, X82166
      Consensus CDS
      CCDS13693.1
      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6
      Related
      ENSP00000381231.4, ENST00000398165.8
      Conserved Domains (1) summary
      TIGR01137
      Location:76 → 544
      cysta_beta; cystathionine beta-synthase

    2. NM_001178008.3 → NP_001171479.1  cystathionine beta-synthase isoform 1

      See identical proteins and their annotated locations for NP_001171479.1

      Status: REVIEWED

      Source sequence(s)
      BC000440, BC010242, HY151461, L19501
      Consensus CDS
      CCDS13693.1
      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6
      Related
      ENSP00000344460.5, ENST00000352178.9
      Conserved Domains (1) summary
      TIGR01137
      Location:76 → 544
      cysta_beta; cystathionine beta-synthase

    3. NM_001178009.3 → NP_001171480.1  cystathionine beta-synthase isoform 1

      See identical proteins and their annotated locations for NP_001171480.1

      Status: REVIEWED

      Source sequence(s)
      BC000440, BC010242, HY151461, L19501
      Consensus CDS
      CCDS13693.1
      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6
      Related
      ENSP00000352643.3, ENST00000359624.7
      Conserved Domains (1) summary
      TIGR01137
      Location:76 → 544
      cysta_beta; cystathionine beta-synthase

    4. NM_001320298.2 → NP_001307227.1  cystathionine beta-synthase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AK294608, AP001630, BC000440, DC315340
      Consensus CDS
      CCDS13693.1
      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6
      Conserved Domains (1) summary
      TIGR01137
      Location:76 → 544
      cysta_beta; cystathionine beta-synthase

    5. NM_001321072.1 → NP_001308001.1  cystathionine beta-synthase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) initiates translation at an alternate start codon compared to variant 1.
      Source sequence(s)
      AP001630
      UniProtKB/TrEMBL
      B7Z6W5
      Related
      ENST00000461686.5
      Conserved Domains (1) summary
      TIGR01137
      Location:1 → 439
      cysta_beta; cystathionine beta-synthase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      43053191..43076873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441030.1 → XP_047296986.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    2. XM_047441024.1 → XP_047296980.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    3. XM_047441025.1 → XP_047296981.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    4. XM_047441021.1 → XP_047296977.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    5. XM_047441031.1 → XP_047296987.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    6. XM_047441027.1 → XP_047296983.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    7. XM_047441023.1 → XP_047296979.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    8. XM_017028491.3 → XP_016883980.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6
      Conserved Domains (1) summary
      TIGR01137
      Location:76 → 544
      cysta_beta; cystathionine beta-synthase

    9. XM_047441020.1 → XP_047296976.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    10. XM_011529777.2 → XP_011528079.1  cystathionine beta-synthase isoform X3

      See identical proteins and their annotated locations for XP_011528079.1

      UniProtKB/TrEMBL
      B7Z2D6
      Conserved Domains (1) summary
      TIGR01137
      Location:76 → 558
      cysta_beta; cystathionine beta-synthase

    11. XM_047441028.1 → XP_047296984.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    12. XM_047441029.1 → XP_047296985.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    13. XM_047441026.1 → XP_047296982.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    14. XM_047441022.1 → XP_047296978.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    15. XM_047441033.1 → XP_047296989.1  cystathionine beta-synthase isoform X7

      UniProtKB/TrEMBL
      B7Z6W5

    16. XM_011529783.2 → XP_011528085.1  cystathionine beta-synthase isoform X6

      UniProtKB/TrEMBL
      B7Z6W5
      Conserved Domains (3) summary
      cd01561
      Location:1 → 278
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      cd04608
      Location:314 → 452
      CBS_pair_PALP_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well ...
      TIGR01137
      Location:1 → 453
      cysta_beta; cystathionine beta-synthase

    17. XM_047441019.1 → XP_047296975.1  cystathionine beta-synthase isoform X2

    18. XM_047441018.1 → XP_047296974.1  cystathionine beta-synthase isoform X2

    19. XM_011529774.3 → XP_011528076.1  cystathionine beta-synthase isoform X1

      See identical proteins and their annotated locations for XP_011528076.1

      Conserved Domains (1) summary
      TIGR01137
      Location:112 → 575
      cysta_beta; cystathionine beta-synthase

    20. XM_047441017.1 → XP_047296973.1  cystathionine beta-synthase isoform X1

    21. XM_047441032.1 → XP_047296988.1  cystathionine beta-synthase isoform X5

      UniProtKB/TrEMBL
      B7Z6W5

    RNA

    1. XR_001754915.2 RNA Sequence

    2. XR_007067793.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      41444310..41468059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324925.1 → XP_054180900.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    2. XM_054324919.1 → XP_054180894.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    3. XM_054324920.1 → XP_054180895.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    4. XM_054324918.1 → XP_054180893.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    5. XM_054324915.1 → XP_054180890.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    6. XM_054324926.1 → XP_054180901.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    7. XM_054324921.1 → XP_054180896.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    8. XM_054324924.1 → XP_054180899.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    9. XM_054324923.1 → XP_054180898.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    10. XM_054324917.1 → XP_054180892.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    11. XM_054324914.1 → XP_054180889.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    12. XM_054324922.1 → XP_054180897.1  cystathionine beta-synthase isoform X4

      UniProtKB/Swiss-Prot
      B2R993, D3DSK4, P35520, Q99425, Q9BWC5
      UniProtKB/TrEMBL
      B7Z2D6

    13. XM_054324916.1 → XP_054180891.1  cystathionine beta-synthase isoform X3

      UniProtKB/TrEMBL
      B7Z2D6

    14. XM_054324930.1 → XP_054180905.1  cystathionine beta-synthase isoform X7

      UniProtKB/TrEMBL
      B7Z6W5

    15. XM_054324929.1 → XP_054180904.1  cystathionine beta-synthase isoform X6

      UniProtKB/TrEMBL
      B7Z6W5

    16. XM_054324913.1 → XP_054180888.1  cystathionine beta-synthase isoform X2

    17. XM_054324912.1 → XP_054180887.1  cystathionine beta-synthase isoform X2

    18. XM_054324911.1 → XP_054180886.1  cystathionine beta-synthase isoform X1

    19. XM_054324910.1 → XP_054180885.1  cystathionine beta-synthase isoform X1

    20. XM_054324927.1 → XP_054180902.1  cystathionine beta-synthase isoform X5

      UniProtKB/TrEMBL
      B7Z6W5

    21. XM_054324928.1 → XP_054180903.1  cystathionine beta-synthase isoform X8

      UniProtKB/TrEMBL
      B7Z2D6

    RNA

    1. XR_008485345.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35520.2 GenPept UniProtKB/Swiss-Prot:P35520

    Gene LinkOut

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