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    BCL6 BCL6 transcription repressor [ Homo sapiens (human) ]

    Gene ID: 604, updated on 4-Jan-2025

    Summary

    Official Symbol
    BCL6provided by HGNC
    Official Full Name
    BCL6 transcription repressorprovided by HGNC
    Primary source
    HGNC:HGNC:1001
    See related
    Ensembl:ENSG00000113916 MIM:109565; AllianceGenome:HGNC:1001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
    Summary
    The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in fat (RPKM 29.2), bone marrow (RPKM 20.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BCL6 in Genome Data Viewer
    Location:
    3q27.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (187721377..187745468, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (190538887..190562977, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187439165..187463256, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene somatostatin Neighboring gene ReSE screen-validated silencer GRCh37_chr3:187416261-187416442 Neighboring gene hCG1645011-like Neighboring gene receptor transporter protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:187455905-187456884 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:187457386-187457561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187458977-187459478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187459479-187459978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:187462369-187462894 Neighboring gene BCL6 antisense RNA 1 Neighboring gene uncharacterized LOC105374263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20970 Neighboring gene uncharacterized LOC105374264 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187580545-187581195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187607545-187608148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187608149-187608752

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (50 hits/1337 screens)

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
    EBI GWAS Catalog
    Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
    EBI GWAS Catalog
    Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
    EBI GWAS Catalog
    Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 6 (BCL6) in human B cells PubMed
    Tat tat HIV-1 Tat upregulates the expression of T-bet, Eomesdermin, Blimp-1, Bcl-6, and Bcl-2 in stimulated but not in unstimulated CD8+T lymphocytes PubMed
    tat HIV-1 Tat upregulates the expression of BCL-6 in Kaposi's sarcoma cells and human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 50
    Process Evidence Code Pubs
    involved_in B cell proliferation  
    involved_in DNA damage response PubMed 
    involved_in Rho protein signal transduction  
    involved_in T-helper 2 cell differentiation  
    involved_in actin cytoskeleton organization  
    involved_in cell morphogenesis  
    involved_in cell motility  
    involved_in cell-matrix adhesion  
    involved_in erythrocyte development  
    involved_in germinal center formation  
    involved_in heterochromatin formation  
    involved_in inflammatory response  
    involved_in isotype switching to IgE isotypes  
    involved_in negative regulation of B cell apoptotic process PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of Notch signaling pathway  
    involved_in negative regulation of Rho protein signal transduction  
    involved_in negative regulation of T-helper 2 cell differentiation  
    involved_in negative regulation of cell growth PubMed 
    involved_in negative regulation of cell-matrix adhesion  
    involved_in negative regulation of cellular senescence  
    involved_in negative regulation of isotype switching to IgE isotypes  
    involved_in negative regulation of mast cell cytokine production  
    involved_in negative regulation of mitotic cell cycle DNA replication PubMed 
    involved_in negative regulation of mononuclear cell proliferation  
    involved_in negative regulation of plasma cell differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in plasma cell differentiation  
    involved_in positive regulation of B cell proliferation  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of cell motility  
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of regulatory T cell differentiation PubMed 
    involved_in protein localization  
    involved_in pyramidal neuron differentiation  
    involved_in regulation of T cell proliferation  
    involved_in regulation of cell differentiation  
    involved_in regulation of cell population proliferation  
    involved_in regulation of cytokine production  
    involved_in regulation of germinal center formation PubMed 
    involved_in regulation of immune response PubMed 
    involved_in regulation of immune system process  
    involved_in regulation of inflammatory response  
    involved_in regulation of memory T cell differentiation  
    involved_in spermatogenesis  
    involved_in transcription by RNA polymerase II  
    involved_in type 2 immune response  
    Items 1 - 25 of 50
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in nucleolus  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in paraspeckles PubMed 
    colocalizes_with replication fork PubMed 

    General protein information

    Preferred Names
    B-cell lymphoma 6 protein
    Names
    B cell CLL/lymphoma 6
    B-cell lymphoma 5 protein
    B-cell lymphoma 6 protein transcript
    BCL-5
    BCL-6
    cys-his2 zinc finger transcription factor
    lymphoma-associated zinc finger gene on chromosome 3
    protein LAZ-3
    zinc finger and BTB domain-containing protein 27
    zinc finger protein 51
    zinc finger transcription factor BCL6S

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007149.1 RefSeqGene

      Range
      5068..29155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130845.2 → NP_001124317.1  B-cell lymphoma 6 protein isoform 1

      See identical proteins and their annotated locations for NP_001124317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a downstream and alternate 5' UTR exon, as compared to variant 1.
      Source sequence(s)
      AC072022, BC146796, BC150184, CN401512
      Consensus CDS
      CCDS3289.1
      UniProtKB/Swiss-Prot
      A7E241, B8PSA7, D3DNV5, P41182
      UniProtKB/TrEMBL
      A5PL18
      Related
      ENSP00000232014.4, ENST00000232014.8
      Conserved Domains (4) summary
      smart00225
      Location:33 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:588 → 613
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001134738.1 → NP_001128210.1  B-cell lymphoma 6 protein isoform 2

      See identical proteins and their annotated locations for NP_001128210.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, as compared to isoform 2.
      Source sequence(s)
      AW337942, BC146796, BC150184, EU883531, Z21943
      Consensus CDS
      CCDS46975.1
      UniProtKB/TrEMBL
      B5B0A5
      Related
      ENSP00000413122.2, ENST00000450123.6
      Conserved Domains (5) summary
      smart00225
      Location:33 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518 → 540
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:532 → 557
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001706.5 → NP_001697.2  B-cell lymphoma 6 protein isoform 1

      See identical proteins and their annotated locations for NP_001697.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
      Source sequence(s)
      BC146796, BC150184, DB079847
      Consensus CDS
      CCDS3289.1
      UniProtKB/Swiss-Prot
      A7E241, B8PSA7, D3DNV5, P41182
      UniProtKB/TrEMBL
      A5PL18
      Related
      ENSP00000384371.2, ENST00000406870.7
      Conserved Domains (4) summary
      smart00225
      Location:33 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:588 → 613
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      187721377..187745468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513062.4 → XP_011511364.1  B-cell lymphoma 6 protein isoform X2

      See identical proteins and their annotated locations for XP_011511364.1

      UniProtKB/TrEMBL
      B5B0A5
      Related
      ENSP00000479784.1, ENST00000621333.4
      Conserved Domains (5) summary
      smart00225
      Location:33 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:520 → 540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:518 → 540
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:532 → 557
      zf-H2C2_2; Zinc-finger double domain
    2. XM_047448655.1 → XP_047304611.1  B-cell lymphoma 6 protein isoform X1

      UniProtKB/Swiss-Prot
      A7E241, B8PSA7, D3DNV5, P41182
      UniProtKB/TrEMBL
      A5PL18
    3. XM_005247694.5 → XP_005247751.1  B-cell lymphoma 6 protein isoform X1

      See identical proteins and their annotated locations for XP_005247751.1

      UniProtKB/Swiss-Prot
      A7E241, B8PSA7, D3DNV5, P41182
      UniProtKB/TrEMBL
      A5PL18
      Conserved Domains (4) summary
      smart00225
      Location:33 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:576 → 596
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:22 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:588 → 613
      zf-H2C2_2; Zinc-finger double domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      190538887..190562977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347430.1 → XP_054203405.1  B-cell lymphoma 6 protein isoform X2

      UniProtKB/TrEMBL
      B5B0A5
    2. XM_054347429.1 → XP_054203404.1  B-cell lymphoma 6 protein isoform X1

      UniProtKB/TrEMBL
      A5PL18
    3. XM_054347428.1 → XP_054203403.1  B-cell lymphoma 6 protein isoform X1

      UniProtKB/TrEMBL
      A5PL18

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