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    livK L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947964, updated on 17-Dec-2024

    Summary

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    Official Symbol
    livK
    Official Full Name
    L-leucine/L-phenylalanine ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG10540
    Locus tag
    b3458
    See related
    ASAP:ABE-0011292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3442; hrbB; hrbC; hrbD
    Summary
    The crystal structure of LivK in both the apo- and ligand-bound form has been determined at 1.5 and 1.8 A resolution . [More information is available at EcoCyc: EG10540].
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    Genomic context

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    Sequence:
    NC_000913.3 (3596451..3597560, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter ATP binding subunit LivG Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM Neighboring gene branched chain amino acid/phenylalanine ABC transporter membrane subunit LivH Neighboring gene PanD maturation factor Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amino-terminal sequence and processing of the precursor of the leucine-specific binding protein, and evidence for conformational differences between the precursor and the mature form. Oxender DL, et al. Proc Natl Acad Sci U S A, 1980 Apr. PMID 6990419, Free PMC Article
    2. Structure of the L-leucine-binding protein refined at 2.4 A resolution and comparison with the Leu/Ile/Val-binding protein structure. Sack JS, et al. J Mol Biol, 1989 Mar 5. PMID 2649683
    3. 19F NMR study of the leucine-specific binding protein of Escherichia coli: mutagenesis and assignment of the 5-fluorotryptophan-labeled residues. Salopek-Sondi B, et al. Protein Eng, 2002 Nov. PMID 12538904
    4. Exploring the role of amino acid-18 of the leucine binding proteins of E. coli. Salopek-Sondi B, et al. J Biomol Struct Dyn, 2002 Dec. PMID 12437376
    5. Sequence and structural similarities between the leucine-specific binding protein and leucyl-tRNA synthetase of Escherichia coli. Williamson RM, et al. Proc Natl Acad Sci U S A, 1990 Jun. PMID 2191293, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-leucine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-leucine transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in L-leucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-leucine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in isoleucine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanine transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in valine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-leucine/L-phenylalanine ABC transporter periplasmic binding protein
    NP_417915.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3596451..3597560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417915.1 L-leucine/L-phenylalanine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417915.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8R8H6
      Conserved Domains (1) summary
      PRK15404
      Location:1 → 369
      PRK15404; high-affinity branched-chain amino acid ABC transporter substrate-binding protein
    Nucleotide Protein
    Heading Accession and Version

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