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    yfhM alpha2-macroglobulin [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947302, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yfhM
    Official Full Name
    alpha2-macroglobulin
    Primary source
    ECOCYC:G7323
    Locus tag
    b2520
    See related
    ASAP:ABE-0008296
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2516
    Summary
    First 17 aa are predicted to be a type II signal peptide. [More information is available at EcoGene: EG13394]. YfhM is predicted to be an 2-macroglobulin involved in colonization . [More information is available at EcoCyc: G7323].
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    Genomic context

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    Sequence:
    NC_000913.3 (2647326..2652287, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene nucleoside diphosphate kinase Neighboring gene peptidoglycan glycosyltransferase PbpC Neighboring gene 3-mercaptopyruvate sulfurtransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Monitoring of gene knockouts: genome-wide profiling of conditionally essential genes. Smith LK, et al. Genome Biol, 2007. PMID 17519022, Free PMC Article
    2. Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition. Garcia-Ferrer I, et al. Proc Natl Acad Sci U S A, 2015 Jul 7. PMID 26100869, Free PMC Article
    3. alpha-Macroglobulins are present in some gram-negative bacteria: characterization of the alpha2-macroglobulin from Escherichia coli. Doan N, et al. J Biol Chem, 2008 Oct 17. PMID 18697741, Free PMC Article
    4. Genome-wide analysis of lipoprotein expression in Escherichia coli MG1655. Brokx SJ, et al. J Bacteriol, 2004 May. PMID 15126489, Free PMC Article
    5. Bacterial alpha2-macroglobulins: colonization factors acquired by horizontal gene transfer from the metazoan genome? Budd A, et al. Genome Biol, 2004. PMID 15186489, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicte that alpha2-macroglobulin alpha2M (ECAM) is a approximately 180-kDa multidomain membrane-anchored pan-peptidase inhibitor.
      Title: Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition.
    2. characterization of the alpha2-macroglobulin from Escherichia coli
      Title: alpha-Macroglobulins are present in some gram-negative bacteria: characterization of the alpha2-macroglobulin from Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha2-macroglobulin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2647326..2652287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417015.1 alpha2-macroglobulin [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417015.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7H9S6G5
      Conserved Domains (1) summary
      COG2373
      Location:1 → 1653
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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