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    wecC UDP-N-acetyl-D-mannosamine dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948977, updated on 3-Dec-2024

    Summary

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    Official Symbol
    wecC
    Official Full Name
    UDP-N-acetyl-D-mannosamine dehydrogenase
    Primary source
    ECOCYC:EG11452
    Locus tag
    b3787
    See related
    ASAP:ABE-0012374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3779; mnaB; rff; rffD
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    Genomic context

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    Sequence:
    NC_000913.3 (3971260..3972522)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase Neighboring gene enterobacterial common antigen polysaccharide co-polymerase Neighboring gene UDP-N-acetylglucosamine 2-epimerase Neighboring gene dTDP-glucose 4,6-dehydratase 2 Neighboring gene glucose-1-phosphate thymidylyltransferase 2 Neighboring gene RffC Neighboring gene dTDP-4-dehydro-6-deoxy-D-glucose transaminase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic synthesis of uridine diphosphate N-acetyl-D-mannosaminuronic acid. Kawamura T, et al. J Biol Chem, 1979 Sep 10. PMID 381306
    2. Cloning and expression of the rfe-rff gene cluster of Escherichia coli. Ohta M, et al. Mol Microbiol, 1991 Aug. PMID 1722555
    3. Genetic location of genes encoding enterobacterial common antigen. Meier U, et al. J Bacteriol, 1985 Aug. PMID 3894334, Free PMC Article
    4. Nucleotide sequence of the Escherichia coli rfe gene involved in the synthesis of enterobacterial common antigen. Molecular cloning of the rfe-rff gene cluster. Meier-Dieter U, et al. J Biol Chem, 1992 Jan 15. PMID 1730666
    5. Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence. Ramos-Morales F, et al. J Bacteriol, 2003 Sep. PMID 12923112, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-N-acetyl-D-mannosamine dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetyl-D-mannosamine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-N-acetyl-D-mannosamine dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in enterobacterial common antigen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in enterobacterial common antigen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetyl-D-mannosamine dehydrogenase
    YP_026254.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3971260..3972522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026254.1 UDP-N-acetyl-D-mannosamine dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026254.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A485JMI6
      Conserved Domains (1) summary
      PRK11064
      Location:1 → 414
      wecC; UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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