U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ycgR flagellar brake protein YcgR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947609, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ycgR
    Official Full Name
    flagellar brake protein YcgR
    Primary source
    ECOCYC:G6623
    Locus tag
    b1194
    See related
    ASAP:ABE-0004009
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1182
    Summary
    YcgR contains a C-terminal PilZ domain, which binds cyclic-di-GMP; binding of c-di-GMP is involved in motility regulation. [More information is available at EcoGene: EG13899]. YcgR regulates flagellar motility in a c-di-GMP-dependent manner in vivo . [More information is available at EcoCyc: G6623].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1243793..1244527, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene murein tetrapeptide carboxypeptidase Neighboring gene lytic murein transglycosylase E Neighboring gene PF04226 family protein YmgE Neighboring gene uncharacterized protein YcgY

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli. Hou YJ, et al. J Biol Chem, 2020 Jan 17. PMID 31836667, Free PMC Article
    2. Crystallization and preliminary X-ray analysis of the flagellar motor `brake' molecule YcgR with c-di-GMP from Escherichia coli. Hou Y, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Jun. PMID 23722848, Free PMC Article
    3. Structural and mechanistic determinants of c-di-GMP signalling. Schirmer T, et al. Nat Rev Microbiol, 2009 Oct. PMID 19756011
    4. Get the message out: cyclic-Di-GMP regulates multiple levels of flagellum-based motility. Wolfe AJ, et al. J Bacteriol, 2008 Jan. PMID 17993515, Free PMC Article
    5. Two novel flagellar components and H-NS are involved in the motor function of Escherichia coli. Ko M, et al. J Mol Biol, 2000 Oct 27. PMID 11031114

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli.
      Title: Structural insights into the mechanism of c-di-GMP-bound YcgR regulating flagellar motility in Escherichia coli.
    2. The crystal structure and structure-function relationship is revealed for YcgR with c-di-GMP.
      Title: Crystallization and preliminary X-ray analysis of the flagellar motor `brake' molecule YcgR with c-di-GMP from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cyclic-di-GMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-di-GMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in bacterial-type flagellum-dependent cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of bacterial-type flagellum-dependent cell motility by regulation of motor speed IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bacterial-type flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in bacterial-type flagellum basal body IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    flagellar brake protein YcgR

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1243793..1244527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415712.1 flagellar brake protein YcgR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415712.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2FV81, A0A8S7CU49
      Conserved Domains (1) summary
      COG5581
      Location:1 → 242
      YcgR; c-di-GMP-binding flagellar brake protein YcgR, contains PilZNR and PilZ domains [Cell motility]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.