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    fre NAD(P)H-flavin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948325, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fre
    Official Full Name
    NAD(P)H-flavin reductase
    Primary source
    ECOCYC:EG10334
    Locus tag
    b3844
    See related
    ASAP:ABE-0012559
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3836; fadI; flrD; fsrC
    Summary
    The fre gene was mistakenly thought to be ubiB. [More information is available at EcoGene: EG10334].
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    Genomic context

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    Sequence:
    NC_000913.3 (4026527..4027228)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3' -> 5' ssDNA/RNA exonuclease TatD Neighboring gene transcription antiterminator RfaH Neighboring gene 3-octaprenyl-4-hydroxybenzoate decarboxylase Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ferric reductases or flavin reductases? Fontecave M, et al. Biometals, 1994 Jan. PMID 8118169
    2. Fre Is the Major Flavin Reductase Supporting Bioluminescence from Vibrio harveyi Luciferase in Escherichia coli. Campbell ZT, et al. J Biol Chem, 2009 Mar 27. PMID 19139094, Free PMC Article
    3. The NAD(P)H:flavin oxidoreductase from Escherichia coli as a source of superoxide radicals. Gaudu P, et al. J Biol Chem, 1994 Mar 18. PMID 8132544
    4. Reduction and mobilization of iron by a NAD(P)H:flavin oxidoreductase from Escherichia coli. Coves J, et al. Eur J Biochem, 1993 Feb 1. PMID 8436123
    5. Cys5 and Cys214 of NAD(P)H:flavin oxidoreductase from Escherichia coli are located in the active site. Fieschi F, et al. Eur J Biochem, 1996 May 1. PMID 8647136

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Characterization of the flavin reductase gene (fre) of Escherichia coli and construction of a plasmid for overproduction of the enzyme.
    2. biochemical analyis of FlRd and its physiological partner, the NADH:flavorubredoxin oxidoreductase FlRd-Red
      Title: Redox and spectroscopic properties of the Escherichia coli nitric oxide-detoxifying system involving flavorubredoxin and its NADH-oxidizing redox partner.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables riboflavin reductase (NAD(P)H) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables riboflavin reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)H-flavin reductase
    NP_418286.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4026527..4027228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418286.1 NAD(P)H-flavin reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418286.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7CST2
      Conserved Domains (1) summary
      PRK08051
      Location:2 → 233
      fre; FMN reductase; Validated
    Nucleotide Protein
    Heading Accession and Version

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