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    cca fused CCA tRNA nucleotidyltransferase/phosphohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947553, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cca
    Official Full Name
    fused CCA tRNA nucleotidyltransferase/phosphohydrolase
    Primary source
    ECOCYC:EG10136
    Locus tag
    b3056
    See related
    ASAP:ABE-0010031
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3046
    Summary
    The CCA C-terminal HD domain has Ni(2+)-dependent phosphatase activity toward pyrophosphate, canonical 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP. [More information is available at EcoGene: EG10136]. tRNA nucleotidyltransferase catalyzes the addition of CCA to the 3' ends of tRNAs in a template-independent manner. [More information is available at EcoCyc: EG10136].
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    Genomic context

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    Sequence:
    NC_000913.3 (3201891..3203129)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inorganic triphosphatase Neighboring gene putative signal transduction protein (SH3 domain) Neighboring gene undecaprenyl pyrophosphate phosphatase Neighboring gene dihydroneopterin aldolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct kinetic determinants for the stepwise CCA addition to tRNA. Kim S, et al. RNA, 2009 Oct. PMID 19696158, Free PMC Article
    2. Kinetic mechanism of tRNA nucleotidyltransferase from Escherichia coli. Williams KR, et al. J Biol Chem, 1977 Aug 10. PMID 18468
    3. Purification and some properties of Escherichia coli tRNA nucleotidyltransferase. Schofield P, et al. J Biol Chem, 1977 Aug 10. PMID 328503
    4. Transfer RNA metabolism in Escherichia coli cells deficient in tRNA nucleotidyltransferase. Deutscher MP, et al. J Mol Biol, 1977 Dec 25. PMID 342706
    5. The -C-C-A end of tRNA and its role in protein biosynthesis. Sprinzl M, et al. Prog Nucleic Acid Res Mol Biol, 1979. PMID 392600

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CCA tRNA nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CCA tRNA nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CCACCA tRNA nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CCACCA tRNA nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CCACCA tRNA nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclic-nucleotide phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA 3'-terminal CCA addition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA 3'-terminal CCA addition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA 3'-terminal CCA addition IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA 3'-terminal CCA addition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA surveillance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fused CCA tRNA nucleotidyltransferase/phosphohydrolase
    NP_417528.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3201891..3203129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417528.1 fused CCA tRNA nucleotidyltransferase/phosphohydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417528.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5C9AGW3
      Conserved Domains (1) summary
      PRK10885
      Location:1 → 409
      cca; multifunctional CCA addition/repair protein
    Nucleotide Protein
    Heading Accession and Version

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