U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    preA dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949037, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    preA
    Official Full Name
    dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA
    Primary source
    ECOCYC:EG11289
    Locus tag
    b2147
    See related
    ASAP:ABE-0007098
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2140; yeiA
    Summary
    HT_Cmplx37_Cyt: [More information is available at EcoGene: EG11289]. Based on sequence similarity, YeiA is predicted to be a dihydrothymine dehydrogenase . [More information is available at EcoCyc: EG11289].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (2235265..2236500)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF218 domain-containing protein SanA Neighboring gene DUF2542 domain-containing protein YeiS Neighboring gene dihydropyrimidine dehydrogenase (NAD(+)) subunit PreT Neighboring gene D-galactose/methyl-galactoside ABC transporter membrane subunit Neighboring gene D-galactose/methyl-galactoside ABC transporter ATP binding subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein. Yoshioka H, et al. J Biochem, 2021 Dec 4. PMID 34097066
    2. Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. Hidese R, et al. J Bacteriol, 2011 Feb. PMID 21169495, Free PMC Article
    3. The iscS gene deficiency affects the expression of pyrimidine metabolism genes. Mihara H, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18482579
    4. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Reed JL, et al. Genome Biol, 2003. PMID 12952533, Free PMC Article
    5. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    contributes_to 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADH dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to dihydropyrimidine dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydropyrimidine dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thymine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uracil catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dihydropyrimidine dehydrogenase (NAD+) complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of oxidoreductase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA
    NP_416652.4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2235265..2236500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416652.4 dihydropyrimidine dehydrogenase (NAD(+)) subunit PreA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416652.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FZC9, A0A377BQG3
      Conserved Domains (1) summary
      PRK08318
      Location:4 → 408
      PRK08318; NAD-dependent dihydropyrimidine dehydrogenase subunit PreA
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.