U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mtlA mannitol-specific PTS enzyme IICBA component [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948118, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mtlA
    Official Full Name
    mannitol-specific PTS enzyme IICBA component
    Primary source
    ECOCYC:EG10615
    Locus tag
    b3599
    See related
    ASAP:ABE-0011761
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3588; mtlC
    Summary
    [More information is available at EcoCyc: EG10615].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (3772281..3774194)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein YibH Neighboring gene DUF3302 domain-containing protein YibI Neighboring gene mannitol-1-phosphate 5-dehydrogenase Neighboring gene transcriptional repressor MtlR Neighboring gene protein YibT

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structure of the cytoplasmic loop between putative helices II and III of the mannitol permease of Escherichia coli: a tryptophan and 5-fluorotryptophan spectroscopy study. Vos EP, et al. Biochemistry, 2009 Jun 16. PMID 19402710
    2. Relation between the oligomerization state and the transport and phosphorylation function of the Escherichia coli mannitol transport protein: interaction between mannitol-specific enzyme II monomers studied by complementation of inactive site-directed mutants. Boer H, et al. Biochemistry, 1996 Oct 1. PMID 8841134
    3. A fluorescence study of single tryptophan-containing mutants of enzyme IImtl of the Escherichia coli phosphoenolpyruvate-dependent mannitol transport system. Dijkstra DS, et al. Biochemistry, 1996 May 28. PMID 8639611
    4. The 5 A projection structure of the transmembrane domain of the mannitol transporter enzyme II. Koning RI, et al. J Mol Biol, 1999 Apr 16. PMID 10222194
    5. Plasmid-directed synthesis of enzymes required for D-mannitol transport and utilization in Escherichia coli. Lee CA, et al. Proc Natl Acad Sci U S A, 1981 Dec. PMID 6801648, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-phosphocysteine-mannitol phosphotransferase system transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-phosphocysteine-sugar phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mannitol transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mannitol transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sorbitol transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mannitol-specific PTS enzyme IICBA component
    NP_418056.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3772281..3774194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418056.1 mannitol-specific PTS enzyme IICBA component [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418056.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M128, A0A8S7EAB5
      Conserved Domains (1) summary
      PRK15083
      Location:1 → 637
      PRK15083; PTS system mannitol-specific transporter subunit IICBA; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.