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    ftsK cell division DNA translocase FtsK [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945102, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ftsK
    Official Full Name
    cell division DNA translocase FtsK
    Primary source
    ECOCYC:G6464
    Locus tag
    b0890
    See related
    ASAP:ABE-0003027
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dinH; ECK0881
    Summary
    FtsK is required for resolution of chromosome dimers at dif by XerCD. [More information is available at EcoGene: EG13226]. FtsK is an essential cell division protein which colocalizes with FtsZ to the septal ring structure; localization is dependent on FtsZ, FtsA and ZipA, but not FtsI and FtsQ . [More information is available at EcoCyc: G6464].
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    Genomic context

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    Sequence:
    NC_000913.3 (933224..937213)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene thioredoxin reductase Neighboring gene DNA-binding transcriptional dual regulator Lrp Neighboring gene outer membrane lipoprotein carrier protein Neighboring gene replication-associated recombination protein A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Study of polymorphic variable-number of tandem repeats loci in the ECOR collection and in a set of pathogenic Escherichia coli and Shigella isolates for use in a genotyping assay. Lindstedt BA, et al. J Microbiol Methods, 2007 Apr. PMID 17291612
    2. A dual role for the FtsK protein in Escherichia coli chromosome segregation. Capiaux H, et al. EMBO Rep, 2002 Jun. PMID 12034757, Free PMC Article
    3. FtsK: Maxwell's Demon? Donachie WD. Mol Cell, 2002 Feb. PMID 11864592
    4. Analysis of DNA supercoil induction by FtsK indicates translocation without groove-tracking. Saleh OA, et al. Nat Struct Mol Biol, 2005 May. PMID 15821742
    5. Delayed activation of Xer recombination at dif by FtsK during septum assembly in Escherichia coli. Kennedy SP, et al. Mol Microbiol, 2008 May. PMID 18363794

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein interaction of FtsK with FTsA is essential to cell division.
      Title: FtsA G50E mutant suppresses the essential requirement for FtsK during bacterial cell division in Escherichia coli.
    2. Deletion of rlpA from an FtsK temperature-sensitive E. coli strain partially restored cell growth and largely suppressed cellular filamentation compared to the wild-type strain. This suggests that interaction with RlpA may be critical in suppressing septation until proper assembly of the divisome.
      Title: Outer membrane lipoprotein RlpA is a novel periplasmic interaction partner of the cell division protein FtsK in Escherichia coli.
    3. FtsKgamma interacts with the C-terminal domain of XerD, above a cleft where XerC is thought to bind. We present a model for activation of recombination based on structural data.
      Title: Activation of Xer-recombination at dif: structural basis of the FtsKγ-XerD interaction.
    4. We found that whatever the growth conditions, sister copies of the V. cholerae chr1 dif region remain together at mid-cell until the onset of constriction, which permits their processing by FtsK and the activation of dif-recombination.
      Title: Fast growth conditions uncouple the final stages of chromosome segregation and cell division in Escherichia coli.
    5. FtsK translocase has a role in assembly, translocation, and activation of XerCD-dif recombination
      Title: Assembly, translocation, and activation of XerCD-dif recombination by FtsK translocase analyzed in real-time by FRET and two-color tethered fluorophore motion.
    6. An average of 7 FtsK hexamers per cell are present at midcell, with the N-terminal domain being able to hexamerize independently of the translocase.
      Title: The N-terminal membrane-spanning domain of the Escherichia coli DNA translocase FtsK hexamerizes at midcell.
    7. Kinetic analyses showed that the presence of the FtsK gamma domain increases the rate of XerCD-dif synapse assembly and increases its stability.
      Title: TPM analyses reveal that FtsK contributes both to the assembly and the activation of the XerCD-dif recombination synapse.
    8. Data indicate that the arrival of the FtsK translocase at an initial synaptic complex, forming a transient activated complex in which XerD exchanged a pair of strands to form an Holliday junctions (HJ) intermediate for catalysis by XerC.
      Title: Conformational transitions during FtsK translocase activation of individual XerCD-dif recombination complexes.
    9. FtsK segregates the terminus region of sister chromosomes whether they are monomeric or dimeric and does so in an accurate and ordered manner.
      Title: FtsK actively segregates sister chromosomes in Escherichia coli.
    10. Multiple regions in FtsK protein are required for in cell division.
      Title: Multiple regions along the Escherichia coli FtsK protein are implicated in cell division.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA translocase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in FtsZ-dependent cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in division septum assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell division site NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of divisome complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division DNA translocase FtsK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      933224..937213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415410.1 cell division DNA translocase FtsK [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415410.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377DUH0
      Conserved Domains (1) summary
      PRK10263
      Location:1 → 1329
      PRK10263; DNA translocase FtsK; Provisional
    Nucleotide Protein
    Heading Accession and Version

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