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    slyA DNA-binding transcriptional dual regulator SlyA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946167, updated on 17-Dec-2024

    Summary

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    Official Symbol
    slyA
    Official Full Name
    DNA-binding transcriptional dual regulator SlyA
    Primary source
    ECOCYC:G6882
    Locus tag
    b1642
    See related
    ASAP:ABE-0005495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1638
    Summary
    SlyA (for "hemolytic protein in Salmonella") was initially identified in Salmonella, although little is known about the regulator role of SlyA. [More information is available at EcoCyc: G6882].
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    Genomic context

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    Sequence:
    NC_000913.3 (1720390..1720824, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene anhydro-N-acetylmuramic acid kinase Neighboring gene outer membrane lipoprotein SlyB Neighboring gene DUF1656 domain-containing protein YdhI Neighboring gene putative membrane fusion protein YdhJ Neighboring gene putative transporter YdhK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon. Curran TD, et al. Microbiology (Reading), 2017 Mar. PMID 28073397, Free PMC Article
    2. Two different open reading frames named slyA in the E. coli sequence databases. Heroven AK, et al. Trends Microbiol, 2002 Jun. PMID 12088660
    3. SlyA, a regulatory protein from Salmonella typhimurium, induces a haemolytic and pore-forming protein in Escherichia coli. Ludwig A, et al. Mol Gen Genet, 1995 Dec 15. PMID 8544813
    4. Induction of haemolytic activity in Escherichia coli by the slyA gene product. Oscarsson J, et al. Mol Microbiol, 1996 Apr. PMID 8861216
    5. Altering the anaerobic transcription factor FNR confers a hemolytic phenotype on Escherichia coli K12. Ralph ET, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724723, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct binding of SlyA to DNA located upstream of a selection of target operons permitted the identification of new operons likely to be directly regulated by SlyA.
      Title: Identification of new members of the Escherichia coli K-12 MG1655 SlyA regulon.
    2. the rarely used UUG initiation codon limits slyA expression and that low SlyA levels limit fimB expression.
      Title: SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12.
    3. At 37 degrees C, SlyA activates transcription of K5 capsule independent of H-NS but maximal transcription requires H-NS.
      Title: Regulation of expression of the region 3 promoter of the Escherichia coli K5 capsule gene cluster involves H-NS, SlyA, and a large 5' untranslated region.
    4. Data Show that SlyA allowed binding of RNA polymerase (RNAP) at the Hemolysin Protein E promoter (PhlyE), but inhibited binding of H-NS.
      Title: Alternate SlyA and H-NS nucleoprotein complexes control hlyE expression in Escherichia coli K-12.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator SlyA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1720390..1720824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416159.2 DNA-binding transcriptional dual regulator SlyA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416159.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A831DTJ0
      Conserved Domains (1) summary
      PRK03573
      Location:1 → 144
      PRK03573; transcriptional regulator SlyA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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