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    Nynrin NYN domain and retroviral integrase containing [ Mus musculus (house mouse) ]

    Gene ID: 277154, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nynrinprovided by MGI
    Official Full Name
    NYN domain and retroviral integrase containingprovided by MGI
    Primary source
    MGI:MGI:2652872
    See related
    Ensembl:ENSMUSG00000075592 AllianceGenome:MGI:2652872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1305
    Summary
    Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in DNA integration. Predicted to be located in membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Orthologous to human NYNRIN (NYN domain and retroviral integrase containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 16.2), CNS E11.5 (RPKM 11.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nynrin in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56091572..56112193)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55854115..55874736)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32092 Neighboring gene receptor-interacting serine-threonine kinase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr14:56441298-56441599 Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Neighboring gene STARR-seq mESC enhancer starr_36783 Neighboring gene STARR-positive B cell enhancer ABC_E7318 Neighboring gene STARR-positive B cell enhancer ABC_E7319 Neighboring gene cerebellin 3 precursor protein Neighboring gene KH and NYN domain containing Neighboring gene short chain dehydrogenase/reductase family 39U, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting. Youngson NA, et al. J Mol Evol, 2005 Oct. PMID 16155747
    2. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1305

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein NYNRIN
    Names
    NYN domain and retroviral integrase catalytic domain-containing protein
    pol-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040072.1 → NP_001035161.1  protein NYNRIN

      See identical proteins and their annotated locations for NP_001035161.1

      Status: VALIDATED

      Source sequence(s)
      BC057379, BC151043
      Consensus CDS
      CCDS49501.1
      UniProtKB/Swiss-Prot
      B9EKP9, Q32KG8, Q3V1I3, Q5DTZ0
      Related
      ENSMUSP00000129557.2, ENSMUST00000168479.3
      Conserved Domains (2) summary
      pfam11977
      Location:739 → 890
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
      cl14782
      Location:1104 → 1207
      RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56091572..56112193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTZ0.2 GenPept UniProtKB/Swiss-Prot:Q5DTZ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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