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    kdgK 2-dehydro-3-deoxygluconokinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948041, updated on 3-Dec-2024

    Summary

    Official Symbol
    kdgK
    Official Full Name
    2-dehydro-3-deoxygluconokinase
    Primary source
    ECOCYC:EG12253
    Locus tag
    b3526
    See related
    ASAP:ABE-0011519
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3511; yhjI
    Summary
    KdgK is elevated 3-5X during growth at 4C (enabled by Oleispira antarctica Cpn10/60 transgene). [More information is available at EcoGene: EG12253]. 2-keto-3-deoxygluconokinase catalyzes the ATP-dependent phosphorylation of the first common intermediate in the D-glucuronate and D-galacturonate degradation pathways, 2-dehydro-3-deoxy-D-gluconate . [More information is available at EcoCyc: EG12253].
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    Genomic context

    Sequence:
    NC_000913.3 (3679419..3680348)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene AsmA family protein YhjG Neighboring gene c-di-GMP phosphodiesterase PdeH Neighboring gene peptidase M16 family protein YhjJ Neighboring gene C4 dicarboxylate/orotate:H(+) symporter

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-dehydro-3-deoxygluconokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 2-dehydro-3-deoxygluconokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 2-dehydro-3-deoxygluconokinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in D-galacturonate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within D-galacturonate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in D-glucuronate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within D-glucuronate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphate-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    2-dehydro-3-deoxygluconokinase
    NP_417983.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3679419..3680348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417983.2 2-dehydro-3-deoxygluconokinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417983.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AN08, A0A8S7HUP5, A0AAD2NU94
      Conserved Domains (1) summary
      cd01166
      Location:4301
      KdgK; 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the ...