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    cheB protein-glutamate methylesterase/protein glutamine deamidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946394, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cheB
    Official Full Name
    protein-glutamate methylesterase/protein glutamine deamidase
    Primary source
    ECOCYC:EG10147
    Locus tag
    b1883
    See related
    ASAP:ABE-0006284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1884
    Summary
    otherPDB (S. typhimurium): [More information is available at EcoGene: EG10147]. The CheB protein consists of two distinct domains: a regulatory domain that accepts a phosphoryl group and a catalytic domain that catalyzes the demethylation and deamidation of MCPs. [More information is available at EcoCyc: EG10147].
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    Genomic context

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    Sequence:
    NC_000913.3 (1967452..1968501, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chemotaxis protein CheZ Neighboring gene chemotaxis protein CheY Neighboring gene chemotaxis protein methyltransferase Neighboring gene methyl-accepting chemotaxis protein Tap

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Location of the receptor-interaction site on CheB, the methylesterase response regulator of bacterial chemotaxis. Barnakov AN, et al. J Biol Chem, 2001 Aug 31. PMID 11435446
    2. Synthesis and biochemical characterization of a phosphorylated analogue of the response regulator CheB. Saxl RL, et al. Biochemistry, 2001 Oct 30. PMID 11669626
    3. Evidence that the methylesterase of bacterial chemotaxis may be a serine hydrolase. Krueger JK, et al. Biochim Biophys Acta, 1992 Mar 12. PMID 1547277
    4. Dynamic map of protein interactions in the Escherichia coli chemotaxis pathway. Kentner D, et al. Mol Syst Biol, 2009. PMID 19156130, Free PMC Article
    5. Evidence for phosphorylation-dependent conformational changes in methylesterase CheB. Anand GS, et al. Protein Sci, 2000 May. PMID 10850799, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Selective Tether Recruits Activated Response Regulator CheB to Its Chemoreceptor Substrate.
      Title: A Selective Tether Recruits Activated Response Regulator CheB to Its Chemoreceptor Substrate.
    2. The exchange of CheB and CheR at receptor clusters shows a strong dependency on the receptor modification.
      Title: Effects of receptor modification and temperature on dynamics of sensory complexes in Escherichia coli chemotaxis.
    3. These studies revealed that the chemotactic response in swimming bacteria is fined-tuned to wild-type level of the [CheR]/[CheB] ratio.
      Title: Fine-tuning of chemotactic response in E. coli determined by high-throughput capillary assay.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables deaminase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay response regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-glutamate methylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glutamate methylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamate methylesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-glutamine glutaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-glutamine glutaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-glutamine glutaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deamination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein demethylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-glutamate methylesterase/protein glutamine deamidase
    NP_416397.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1967452..1968501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416397.1 protein-glutamate methylesterase/protein glutamine deamidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416397.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WPH6
      Conserved Domains (1) summary
      PRK00742
      Location:1 → 345
      PRK00742; chemotaxis-specific protein-glutamate methyltransferase CheB
    Nucleotide Protein
    Heading Accession and Version

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