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    nikE Ni(2(+)) ABC transporter ATP binding subunit NikE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947987, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nikE
    Official Full Name
    Ni(2(+)) ABC transporter ATP binding subunit NikE
    Primary source
    ECOCYC:EG12079
    Locus tag
    b3480
    See related
    ASAP:ABE-0011362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3464; hydC; hydD
    Summary
    Mutants display nickel-remediated formate hydrogen-lyase, hydrogenase, and hydrogenase-related fumarase defects. [More information is available at EcoGene: EG12079]. The NikABCDE ATP-dependent nickel (II) uptake system is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG12079].
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    Genomic context

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    Sequence:
    NC_000913.3 (3617776..3618582)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Ni(2(+)) ABC transporter periplasmic binding protein Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikB Neighboring gene Ni(2(+)) ABC transporter membrane subunit NikC Neighboring gene Ni(2(+)) ABC transporter ATP binding subunit NikD Neighboring gene DNA-binding transcriptional repressor NikR Neighboring gene rhs element protein RhsB Neighboring gene PF15631 family protein YhhH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and physiological characterization of new Escherichia coli mutants impaired in hydrogenase activity. Wu LF, et al. Biochimie, 1986 Jan. PMID 3089308
    2. Identification of Ni-(L-His)₂ as a substrate for NikABCDE-dependent nickel uptake in Escherichia coli. Chivers PT, et al. Metallomics, 2012 Oct. PMID 22885853
    3. The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli. Wu LF, et al. Gene, 1991 Oct 30. PMID 1743519
    4. Purification and characterization of the periplasmic nickel-binding protein NikA of Escherichia coli K12. de Pina K, et al. Eur J Biochem, 1995 Feb 1. PMID 7867647
    5. Crystallographic and spectroscopic evidence for high affinity binding of FeEDTA(H2O)- to the periplasmic nickel transporter NikA. Cherrier MV, et al. J Am Chem Soc, 2005 Jul 20. PMID 16011372

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type nickel transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in nickel cation import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nickel cation import across plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in nickel cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ni(2(+)) ABC transporter ATP binding subunit NikE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3617776..3618582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417937.1 Ni(2(+)) ABC transporter ATP binding subunit NikE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417937.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FST8
      Conserved Domains (1) summary
      PRK10419
      Location:1 → 268
      nikE; nickel ABC transporter ATP-binding protein NikE
    Nucleotide Protein
    Heading Accession and Version

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