ZNF117 zinc finger protein 117 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF117provided by HGNC
Official Full Name: zinc finger protein 117provided by HGNC
Primary source: HGNC:HGNC:12897
See related: Ensembl:ENSG00000152926 MIM:194624; AllianceGenome:HGNC:12897
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPF9; H-plk
Summary: This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Readthrough transcription occurs between this gene and the upstream endogenous retrovirus group 3 member 1 (ERV3-1) locus, and may result in additional transcript variants encoding the zinc finger protein. [provided by RefSeq, Jan 2017]
Expression: Ubiquitous expression in adrenal (RPKM 13.2), fat (RPKM 12.9) and 23 other tissues See more
Orthologs: all
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Genomic context

Location:: 7q11.21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (64971772..64991036, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (66177975..66197217, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (64432150..64451414, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480789

ERV3 (e-PCR)
- UniSTS:42787

ERV3 (e-PCR)
- UniSTS:77360

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-36553 (e-PCR)
- UniSTS:6457

SHGC-77159 (e-PCR)
- UniSTS:42353

SHGC-32256 (e-PCR)
- UniSTS:46220

NoName (e-PCR)
- UniSTS:489874

RH17834 (e-PCR)
- UniSTS:86452

RH70049 (e-PCR)
- UniSTS:83644

NoName (e-PCR)
- UniSTS:486333

NoName (e-PCR)
- UniSTS:481985

NoName (e-PCR)
- UniSTS:494556

RH80031 (e-PCR)
- UniSTS:91103

Readthrough ERV3-1-ZNF117

Readthrough gene: ERV3-1-ZNF117, Included gene: ERV3-1

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 117

Names: Krueppel-related zinc finger protein; provirus-linked krueppel; zinc finger protein HPF9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015852.5 → NP_056936.2 zinc finger protein 117

See identical proteins and their annotated locations for NP_056936.2

Status: VALIDATED

Source sequence(s)

AC073210

UniProtKB/Swiss-Prot

Q02313, Q03924, Q7Z7Q7

Related

ENSP00000282869.5, ENST00000282869.11

Conserved Domains (2) summary

COG5048
Location:163 → 475

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:279 → 299

ZF_C2H2; C2H2 Zn finger [structural motif]