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    Zcchc7 zinc finger CCHC-type containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298086, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zcchc7provided by RGD
    Official Full Name
    zinc finger CCHC-type containing 7provided by RGD
    Primary source
    RGD:1310467
    See related
    EnsemblRapid:ENSRNOG00000013078 AllianceGenome:RGD:1310467
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in nuclear RNA surveillance. Predicted to be located in cytosol and nucleolus. Predicted to be part of TRAMP complex. Orthologous to human ZCCHC7 (zinc finger CCHC-type containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 302.9), Thymus (RPKM 220.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zcchc7 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (63787292..63968960)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (58992558..59173308)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60250546..60430119)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K-like Neighboring gene paired box 5 Neighboring gene uncharacterized LOC120102862 Neighboring gene uncharacterized LOC134487064 Neighboring gene uncharacterized LOC120102863

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent snRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent snoRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 7
    Names
    TRAMP-like complex RNA-binding factor ZCCHC7
    zinc finger, CCHC domain containing 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106658.2 → NP_001100128.1  zinc finger CCHC domain-containing protein 7

      See identical proteins and their annotated locations for NP_001100128.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161967
      UniProtKB/Swiss-Prot
      B1WC15
      UniProtKB/TrEMBL
      F1M989
      Related
      ENSRNOP00000082347.1, ENSRNOT00000112430.2
      Conserved Domains (2) summary
      COG5082
      Location:235 → 364
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      TIGR01622
      Location:381 → 473
      SF-CC1; splicing factor, CC1-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      63787292..63968960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109462.2 → XP_038965390.1  zinc finger CCHC domain-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      B1WC15
      UniProtKB/TrEMBL
      F1M989
      Related
      ENSRNOP00000017707.7, ENSRNOT00000017707.8
      Conserved Domains (2) summary
      COG5082
      Location:235 → 364
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      TIGR01622
      Location:381 → 473
      SF-CC1; splicing factor, CC1-like family

    2. XM_063287336.1 → XP_063143406.1  zinc finger CCHC domain-containing protein 7 isoform X2

    3. XM_063287337.1 → XP_063143407.1  zinc finger CCHC domain-containing protein 7 isoform X3

    4. XM_039109461.2 → XP_038965389.1  zinc finger CCHC domain-containing protein 7 isoform X1

      UniProtKB/Swiss-Prot
      B1WC15
      UniProtKB/TrEMBL
      F1M989
      Conserved Domains (2) summary
      COG5082
      Location:235 → 364
      AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
      TIGR01622
      Location:381 → 473
      SF-CC1; splicing factor, CC1-like family

    5. XM_063287338.1 → XP_063143408.1  zinc finger CCHC domain-containing protein 7 isoform X3

    RNA

    1. XR_005504380.2 RNA Sequence

    2. XR_005504382.2 RNA Sequence

    3. XR_005504381.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1WC15.1 GenPept UniProtKB/Swiss-Prot:B1WC15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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