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    yeiG S-formylglutathione hydrolase/S-lactoylglutathione hydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949045, updated on 3-Dec-2024

    Summary

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    Official Symbol
    yeiG
    Official Full Name
    S-formylglutathione hydrolase/S-lactoylglutathione hydrolase
    Primary source
    ECOCYC:EG12026
    Locus tag
    b2154
    See related
    ASAP:ABE-0007124
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2147
    Summary
    YeiG and FrmB are 50% identical paralogs; double mutant is formaldehyde sensitive. [More information is available at EcoGene: EG12026]. YeiG is a promiscuous serine hydrolase; its highest specific activity is with the substrate S-formylglutathione. [More information is available at EcoCyc: EG12026].
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    Genomic context

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    Sequence:
    NC_000913.3 (2243910..2244746)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF418 domain-containing protein YeiB Neighboring gene GTP cyclohydrolase 1 Neighboring gene iron-catecholate outer membrane transporter CirA Neighboring gene lysine:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG. Gonzalez CF, et al. J Biol Chem, 2006 May 19. PMID 16567800
    2. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
    3. Enzyme genomics: Application of general enzymatic screens to discover new enzymes. Kuznetsova E, et al. FEMS Microbiol Rev, 2005 Apr. PMID 15808744
    4. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. and YeiG are S-formylglutathione hydrolases with a Ser-His-Asp catalytic triad involved in the detoxification of formaldehyde in E. coli
      Title: Molecular basis of formaldehyde detoxification. Characterization of two S-formylglutathione hydrolases from Escherichia coli, FrmB and YeiG.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-formylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-formylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within formaldehyde catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    S-formylglutathione hydrolase/S-lactoylglutathione hydrolase
    NP_416659.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2243910..2244746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416659.1 S-formylglutathione hydrolase/S-lactoylglutathione hydrolase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416659.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EE56
      Conserved Domains (1) summary
      cl21494
      Location:8 → 276
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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