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    Mastl microtubule associated serine/threonine kinase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307169, updated on 9-Dec-2024

    Summary

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    Symbol
    Mastlprovided by RGD
    Full Name
    microtubule associated serine/threonine kinase-likeprovided by RGD
    Primary source
    RGD:1309186
    See related
    EnsemblRapid:ENSRNOG00000054474 AllianceGenome:RGD:1309186
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; meiotic chromosome condensation; and positive regulation of meiotic cell cycle process involved in oocyte maturation. Predicted to act upstream of or within female meiosis II and positive regulation of ubiquitin protein ligase activity. Predicted to be located in cleavage furrow; microtubule cytoskeleton; and nucleoplasm. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 68.8), Spleen (RPKM 37.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mastl in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (90158592..90195550, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (85250512..85287479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (89839562..89875855)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene acyl-CoA binding domain containing 5 Neighboring gene YME1-like 1 ATPase Neighboring gene POTE ankyrin domain family, member C Neighboring gene ankyrin repeat domain-containing protein 26-like Neighboring gene sperm motility kinase X-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Greatwall kinase is required for meiotic maturation in porcine oocytes. Li YH, et al. Biol Reprod, 2013 Sep. PMID 23843240
    2. MASTL is the human orthologue of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis. Voets E, et al. Cell Cycle, 2010 Sep 1. PMID 20818157
    3. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Burgess A, et al. Proc Natl Acad Sci U S A, 2010 Jul 13. PMID 20538976, Free PMC Article
    4. FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. Gandhi MJ, et al. Hum Hered, 2003. PMID 12890928
    5. Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II. Adhikari D, et al. J Cell Biol, 2014 Sep 29. PMID 25246615, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within female meiosis II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in meiotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase greatwall
    Names
    microtubule-associated serine/threonine-protein kinase-like
    serine/threonine-protein kinase greatwall-like
    NP_001100839.1
    XP_006254402.1
    XP_006254403.1
    XP_063132572.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107369.1 → NP_001100839.1  serine/threonine-protein kinase greatwall

      See identical proteins and their annotated locations for NP_001100839.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474100
      UniProtKB/TrEMBL
      A6KRZ2, D4A355
      Conserved Domains (3) summary
      smart00220
      Location:34 → 194
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05610
      Location:29 → 222
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:659 → 857
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      90158592..90195550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276502.1 → XP_063132572.1  serine/threonine-protein kinase greatwall isoform X3

      UniProtKB/TrEMBL
      D4A355
      Related
      ENSRNOP00000085820.2, ENSRNOT00000106298.2

    2. XM_006254341.5 → XP_006254403.1  serine/threonine-protein kinase greatwall isoform X2

      UniProtKB/TrEMBL
      D4A355
      Conserved Domains (2) summary
      smart00220
      Location:34 → 148
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:613 → 812
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006254340.5 → XP_006254402.1  serine/threonine-protein kinase greatwall isoform X1

      UniProtKB/TrEMBL
      D4A355
      Related
      ENSRNOP00000074792.2, ENSRNOT00000077899.3
      Conserved Domains (3) summary
      smart00220
      Location:34 → 194
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05610
      Location:29 → 222
      STKc_MASTL; Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase)
      cl21453
      Location:659 → 858
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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