Rnase1 ribonuclease A family member 1, pancreatic [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Rnase1provided by RGD
Full Name: ribonuclease A family member 1, pancreaticprovided by RGD
Primary source: RGD:3574
See related: EnsemblRapid:ENSRNOG00000063584 AllianceGenome:RGD:3574
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RL1; Rib1
Summary: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to act upstream of or within response to bacterium. Predicted to be located in cytosol and lysosomal lumen. Orthologous to human RNASE1 (ribonuclease A family member 1, pancreatic). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 2331.6) and Liver (RPKM 722.0) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (26835436..26837145, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (24361924..24363633, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	Unplaced Scaffold	NW_007906778.1 (56808..58359, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular evolution and gene duplication
Title: Pancreatic-type ribonuclease 1 gene duplications in rat species.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ribonuclease A activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosomal lumen	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: ribonuclease pancreatic beta-type

Names: RNase 1 gamma; RNase A; pancreatic ribonuclease; ribonuclease 1 pancreatic; ribonuclease RNase A family 1; ribonuclease, RNase A family, 1 (pancreatic)

NP_001025075.2

EC 4.6.1.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029904.2 → NP_001025075.2 ribonuclease pancreatic beta-type precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

P00684

UniProtKB/TrEMBL

A6KED8

Related

ENSRNOP00000068653.3, ENSRNOT00000086427.3

Conserved Domains (1) summary

smart00092
Location:29 → 152

RNAse_Pc; Pancreatic ribonuclease