Gpr158 G protein-coupled receptor 158 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr158provided by RGD
Official Full Name: G protein-coupled receptor 158provided by RGD
Primary source: RGD:1305841
See related: EnsemblRapid:ENSRNOG00000024832 AllianceGenome:RGD:1305841
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: mGlyR
Summary: Predicted to enable G protein-coupled glycine receptor activity and enzyme activator activity. Predicted to be involved in several processes, including positive regulation of neurotransmitter secretion; protein localization to plasma membrane; and regulation of G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in postsynaptic density membrane. Orthologous to human GPR158 (G protein-coupled receptor 158). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 239.7), Lung (RPKM 16.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (88685879..89152659)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (83777625..84244428)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (88215131..88654352)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus.
Title: Hyperglycemic microenvironment compromises the homeostasis of communication between the bone-brain axis by the epigenetic repression of the osteocalcin receptor, Gpr158 in the hippocampus.

Submit: New GeneRIF Correction

General gene information

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Markers

BE119491 (e-PCR)
- UniSTS:249199

D17Got107 (e-PCR)
- UniSTS:113902

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled glycine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled glycine receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled glycine receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme activator activity	IEA Inferred from Electronic Annotation more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in cognition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metabotropic glycine receptor

Names: probable G-protein coupled receptor 158

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170326.1 → NP_001163797.1 metabotropic glycine receptor precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

D4A6L0

Related

ENSRNOP00000038884.6, ENSRNOT00000034098.9

Conserved Domains (1) summary

cd15293
Location:415 → 672

7tmC_GPR158-like; orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

88685879..89152659

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095563.2 → XP_038951491.1 metabotropic glycine receptor isoform X1

UniProtKB/Swiss-Prot

D4A6L0

Conserved Domains (1) summary

cd15293
Location:415 → 672

7tmC_GPR158-like; orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors
XM_039095564.2 → XP_038951492.1 metabotropic glycine receptor isoform X1

UniProtKB/Swiss-Prot

D4A6L0

Conserved Domains (1) summary

cd15293
Location:415 → 672

7tmC_GPR158-like; orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors