Prg4 proteoglycan 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prg4provided by RGD
Official Full Name: proteoglycan 4provided by RGD
Primary source: RGD:1308976
See related: EnsemblRapid:ENSRNOG00000002385 AllianceGenome:RGD:1308976
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable polysaccharide binding activity and scavenger receptor activity. Predicted to be involved in immune response and vesicle-mediated transport. Predicted to act upstream of or within hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 64.7), Liver (RPKM 36.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (65037363..65054764, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (62487257..62504657, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (67672588..67688902, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRG4 mitigates hemorrhagic shock-induced cardiac injury by inhibiting mitochondrial dysregulation, oxidative stress and NLRP3-mediated pyroptosis.
Title: PRG4 mitigates hemorrhagic shock-induced cardiac injury by inhibiting mitochondrial dysregulation, oxidative stress and NLRP3-mediated pyroptosis.
Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity.
Title: Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity.
Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis.
Title: Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis.
Effects of in vivo cyclic compressive loading on the distribution of local Col2 and superficial lubricin in rat knee cartilage.
Title: Effects of in vivo cyclic compressive loading on the distribution of local Col2 and superficial lubricin in rat knee cartilage.
sinusoidal electromagnetic fields exposure can promote lubricin synthesis of rat chondrocytes.
Title: Effects of electromagnetic fields on the metabolism of lubricin of rat chondrocytes.
Data suggest that moderate physical activity and normal mechanical joint loading in elderly rats improve tribology and lubricative properties of articular cartilage, promoting lubricin synthesis and its elevation in synovial fluid.
Title: Physical activity ameliorates cartilage degeneration in a rat model of aging: a study on lubricin expression.
The objective of this study was to characterize and quantify the effect of ESWT on lubricin expression in tendons and septa in a rat model.[Lubricin]
Title: Extracorporeal shockwave-induced expression of lubricin in tendons and septa.
Results showed that protein and mRNA levels of lubricin increased in normal cartilage but decreased in osteoarthritic cartilage.
Title: Co-Expression and Co-Localization of Cartilage Glycoproteins CHI3L1 and Lubricin in Osteoarthritic Cartilage: Morphological, Immunohistochemical and Gene Expression Profiles.
Cartilage derived from MSCs expressed lubricin protein both in vitro and in vivo
Title: Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo.
Data indicate a marked intensity-specific effect of running on the immunolocalisation and gene expression of lubricin (proteoglycan 4) in cartilage.
Title: Intensity-dependent effect of treadmill running on lubricin metabolism of rat articular cartilage.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

RH136904 (e-PCR)
- UniSTS:218993

RH138961 (e-PCR)
- UniSTS:221047

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hematopoietic stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proteoglycan 4

Names: lubricin; proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105962.4 → NP_001099432.4 proteoglycan 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LRA5

Related

ENSRNOP00000059900.4, ENSRNOT00000068148.5

Conserved Domains (3) summary

smart00201
Location:26 → 68

SO; Somatomedin B -like domains

PHA03247
Location:315 → 724

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:1013 → 1274

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

65037363..65054764 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090463.2 → XP_038946391.1 proteoglycan 4 isoform X1

UniProtKB/TrEMBL

F1LRA5

Conserved Domains (3) summary

smart00201
Location:26 → 68

SO; Somatomedin B -like domains

PHA03247
Location:315 → 724

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:1013 → 1274

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
XM_039090465.2 → XP_038946393.1 proteoglycan 4 isoform X3

UniProtKB/TrEMBL

F1LRA5

Related

ENSRNOP00000103368.1, ENSRNOT00000154575.1

Conserved Domains (3) summary

smart00201
Location:25 → 67

SO; Somatomedin B -like domains

PHA03247
Location:274 → 683

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:972 → 1233

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
XM_039090464.2 → XP_038946392.1 proteoglycan 4 isoform X2

UniProtKB/TrEMBL

F1LRA5

Related

ENSRNOP00000112824.1, ENSRNOT00000126171.1

Conserved Domains (3) summary

smart00201
Location:26 → 68

SO; Somatomedin B -like domains

PHA03247
Location:275 → 684

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:973 → 1234

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
XM_039090466.2 → XP_038946394.1 proteoglycan 4 isoform X4

UniProtKB/TrEMBL

A0A8I6A1N7, F1LRA5

Related

ENSRNOP00000086666.1, ENSRNOT00000113690.2

Conserved Domains (3) summary

smart00201
Location:26 → 68

SO; Somatomedin B -like domains

PHA03247
Location:227 → 636

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:925 → 1186

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
XM_039090467.2 → XP_038946395.1 proteoglycan 4 isoform X5

UniProtKB/TrEMBL

F1LRA5

Conserved Domains (3) summary

smart00201
Location:25 → 65

SO; Somatomedin B -like domains

PHA03247
Location:186 → 595

PHA03247; large tegument protein UL36; Provisional

cd00094
Location:884 → 1145

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...