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    Tmx1 thioredoxin-related transmembrane protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmx1provided by RGD
    Official Full Name
    thioredoxin-related transmembrane protein 1provided by RGD
    Primary source
    RGD:1308455
    See related
    EnsemblRapid:ENSRNOG00000057934 AllianceGenome:RGD:1308455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Txndc1
    Summary
    Predicted to enable enzyme inhibitor activity; protein disulfide isomerase activity; and protein-disulfide reductase activity. Predicted to be involved in several processes, including negative regulation of platelet aggregation; negative regulation of triglyceride biosynthetic process; and positive regulation of ERAD pathway. Predicted to be active in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 285.3), Brain (RPKM 251.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmx1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (94696699..94707751)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (88960691..88971744)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (92864123..92875141)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549102 Neighboring gene sorting nexin 7, pseudogene 1 Neighboring gene uncharacterized LOC102551922 Neighboring gene uncharacterized LOC120103546 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC102552060

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Reductive activation of type 2 ribosome-inactivating proteins is promoted by transmembrane thioredoxin-related protein. Pasetto M, et al. J Biol Chem, 2012 Mar 2. PMID 22228764, Free PMC Article
    2. Identification of a novel thioredoxin-related transmembrane protein. Matsuo Y, et al. J Biol Chem, 2001 Mar 30. PMID 11152479
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables disulfide oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables disulfide oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-related transmembrane protein 1
    Names
    thioredoxin domain containing 1
    NP_001019971.1
    XP_006240240.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024800.2 → NP_001019971.1  thioredoxin-related transmembrane protein 1 precursor

      See identical proteins and their annotated locations for NP_001019971.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K1D9, Q52KJ9
      Related
      ENSRNOP00000081790.1, ENSRNOT00000100740.2
      Conserved Domains (1) summary
      cd02994
      Location:29 → 129
      PDI_a_TMX; PDIa family, TMX subfamily; composed of proteins similar to the TRX-related human transmembrane protein, TMX. TMX is a type I integral membrane protein; the N-terminal redox active TRX domain is present in the endoplasmic reticulum (ER) lumen while the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      94696699..94707751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240178.5 → XP_006240240.1  thioredoxin-related transmembrane protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1Z5
      Related
      ENSRNOP00000071802.3, ENSRNOT00000087540.3
      Conserved Domains (1) summary
      cl00388
      Location:70 → 149
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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