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    Snai3 snail family transcriptional repressor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snai3provided by RGD
    Official Full Name
    snail family transcriptional repressor 3provided by RGD
    Primary source
    RGD:1309658
    See related
    EnsemblRapid:ENSRNOG00000013586 AllianceGenome:RGD:1309658
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human SNAI3 (snail family transcriptional repressor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 9.7), Muscle (RPKM 9.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snai3 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67425311..67437830, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50516771..50529295, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55276211..55290031, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-245 alpha chain Neighboring gene mevalonate diphosphate decarboxylase Neighboring gene ring finger protein 166 Neighboring gene cytosolic thiouridylase subunit 2 Neighboring gene piezo-type mechanosensitive ion channel component 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs. Kataoka H, et al. Nucleic Acids Res, 2000 Jan 15. PMID 10606664, Free PMC Article
    2. Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin). Hale JS, et al. J Leukoc Biol, 2006 Aug. PMID 16735694
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein SNAI3
    Names
    snail family zinc finger 3
    snail homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107439.1 → NP_001100909.1  zinc finger protein SNAI3

      See identical proteins and their annotated locations for NP_001100909.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IZS1, D3ZYQ2
      Conserved Domains (3) summary
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:219 → 242
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67425311..67437830 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097781.2 → XP_038953709.1  zinc finger protein SNAI3 isoform X2

      Conserved Domains (5) summary
      PHA00733
      Location:181 → 226
      PHA00733; hypothetical protein
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152 → 172
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:207 → 229
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:222 → 245
      zf-H2C2_2; Zinc-finger double domain

    2. XM_008772611.4 → XP_008770833.1  zinc finger protein SNAI3 isoform X1

      Related
      ENSRNOP00000110842.1, ENSRNOT00000154954.1
      Conserved Domains (5) summary
      COG5048
      Location:250 → 295
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:247 → 267
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:273 → 295
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:260 → 283
      zf-H2C2_2; Zinc-finger double domain

    3. XM_063278067.1 → XP_063134137.1  zinc finger protein SNAI3 isoform X3

      UniProtKB/TrEMBL
      A6IZS1, D3ZYQ2

    4. XM_063278066.1 → XP_063134136.1  zinc finger protein SNAI3 isoform X3

      UniProtKB/TrEMBL
      A6IZS1, D3ZYQ2

    5. XM_008772612.4 → XP_008770834.1  zinc finger protein SNAI3 isoform X3

      See identical proteins and their annotated locations for XP_008770834.1

      UniProtKB/TrEMBL
      A6IZS1, D3ZYQ2
      Conserved Domains (3) summary
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:149 → 169
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:219 → 242
      zf-H2C2_2; Zinc-finger double domain

    6. XM_006255765.4 → XP_006255827.1  zinc finger protein SNAI3 isoform X4

      Related
      ENSRNOP00000018387.5, ENSRNOT00000018387.8
      Conserved Domains (5) summary
      COG5048
      Location:201 → 246
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:198 → 218
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:141 → 161
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:224 → 246
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:211 → 234
      zf-H2C2_2; Zinc-finger double domain

    7. XM_063278068.1 → XP_063134138.1  zinc finger protein SNAI3 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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