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    Zfp281 zinc finger protein 281 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp281provided by RGD
    Official Full Name
    zinc finger protein 281provided by RGD
    Primary source
    RGD:1305139
    See related
    EnsemblRapid:ENSRNOG00000058643 AllianceGenome:RGD:1305139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic body morphogenesis; regulation of gene expression; and stem cell differentiation. Predicted to be located in nucleoplasm. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 159.5), Adrenal (RPKM 117.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp281 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (50647750..50655912)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (48096103..48104265)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (53531080..53534399)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide B2, pseudogene 1 Neighboring gene transfer RNA proline (anticodon AGG) 34 Neighboring gene uncharacterized LOC102547588 Neighboring gene uncharacterized LOC120096258 Neighboring gene uncharacterized LOC134481566

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression. Law DJ, et al. Biochem Biophys Res Commun, 1999 Aug 19. PMID 10448078
    2. Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence. Lisowsky T, et al. FEBS Lett, 1999 Jun 25. PMID 10405178
    3. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Fidalgo M, et al. Stem Cells, 2011 Nov. PMID 21915945, Free PMC Article
    4. Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Fidalgo M, et al. Proc Natl Acad Sci U S A, 2012 Oct 2. PMID 22988117, Free PMC Article
    5. ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1. Zhang X, et al. Nucleic Acids Res, 2003 Jun 1. PMID 12771217, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic body morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 281

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012030.1 → NP_001012030.1  zinc finger protein 281

      See identical proteins and their annotated locations for NP_001012030.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083844
      UniProtKB/TrEMBL
      A0A0G2K3M5, A6ICJ2, Q5XI48
      Conserved Domains (3) summary
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:324 → 349
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:254 → 276
      zf-C2H2_4; C2H2-type zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      50647750..50655912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090831.1 → XP_038946759.1  zinc finger protein 281 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3M5, A6ICJ2, Q5XI48
      Related
      ENSRNOP00000099455.1, ENSRNOT00000165137.1
      Conserved Domains (3) summary
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:324 → 349
      zf-H2C2_2; Zinc-finger double domain
      pfam13894
      Location:254 → 276
      zf-C2H2_4; C2H2-type zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version

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