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    edd phosphogluconate dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946362, updated on 3-Dec-2024

    Summary

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    Official Symbol
    edd
    Official Full Name
    phosphogluconate dehydratase
    Primary source
    ECOCYC:EG10257
    Locus tag
    b1851
    See related
    ASAP:ABE-0006166
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1852
    Summary
    There has been little work done on this enzyme in Escherichia coli. [More information is available at EcoCyc: EG10257].
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    Genomic context

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    Sequence:
    NC_000913.3 (1932793..1934604, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoribosylglycinamide formyltransferase 2 Neighboring gene KHG/KDPG aldolase Neighboring gene NADP(+)-dependent glucose-6-phosphate dehydrogenase Neighboring gene DNA-binding transcriptional repressor YebK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase. Gardner PR, et al. J Biol Chem, 1991 Jan 25. PMID 1846355
    2. Glucose and gluconate metabolism in a mutant of Escherichia coli lacking gluconate-6-phosphate dehydrase. Zablotny R, et al. J Bacteriol, 1967 May. PMID 5337844, Free PMC Article
    3. Gluconate metabolism in Escherichia coli. Eisenberg RC, et al. J Bacteriol, 1967 Mar. PMID 5337840, Free PMC Article
    4. The Entner-Doudoroff pathway: history, physiology and molecular biology. Conway T. FEMS Microbiol Rev, 1992 Sep. PMID 1389313
    5. Molecular characterization of the Entner-Doudoroff pathway in Escherichia coli: sequence analysis and localization of promoters for the edd-eda operon. Egan SE, et al. J Bacteriol, 1992 Jul. PMID 1624451, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphogluconate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphogluconate dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphogluconate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphogluconate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-gluconate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within D-gluconate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in D-gluconate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Entner-Doudoroff pathway through 6-phosphogluconate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphogluconate dehydratase
    NP_416365.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1932793..1934604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416365.1 phosphogluconate dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416365.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A403CSJ0, A0A8S7CKQ8
      Conserved Domains (1) summary
      PRK09054
      Location:1 → 603
      PRK09054; phosphogluconate dehydratase; Validated
    Nucleotide Protein
    Heading Accession and Version

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