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    ilvD dihydroxy-acid dehydratase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948277, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ilvD
    Official Full Name
    dihydroxy-acid dehydratase
    Primary source
    ECOCYC:EG10496
    Locus tag
    b3771
    See related
    ASAP:ABE-0012318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3763
    Summary
    Dihydroxy-acid dehydratase carries out the penultimate step in both the isoleucine and valine biosynthesis pathways. [More information is available at EcoCyc: EG10496].
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    Genomic context

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    Sequence:
    NC_000913.3 (3953478..3955328)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene acetolactate synthase II subunit IlvM Neighboring gene branched-chain-amino-acid aminotransferase Neighboring gene threonine deaminase Neighboring gene DNA-binding transcriptional dual regulator IlvY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reactivity of nitric oxide with the [4Fe-4S] cluster of dihydroxyacid dehydratase from Escherichia coli. Duan X, et al. Biochem J, 2009 Feb 1. PMID 18945212, Free PMC Article
    2. Physical organization of the ilvEDAC genes of Escherichia coli strain K-12. McCorkle GM, et al. Proc Natl Acad Sci U S A, 1978 Jan. PMID 343113, Free PMC Article
    3. Dihydroxyacid dehydratase: the site of hyperbaric oxygen poisoning in branch-chain amino acid biosynthesis. Brown OR, et al. Biochem Biophys Res Commun, 1978 Dec 14. PMID 367373
    4. An activity stain for dihydroxy-acid dehydratase. Kuo CF, et al. Anal Biochem, 1987 Aug 1. PMID 2445227
    5. A reverse-phase high-performance liquid chromatography assay for dihydroxy-acid dehydratase. Smyk-Randall EM, et al. Anal Biochem, 1987 Aug 1. PMID 3314584

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: The role and properties of the iron-sulfur cluster in Escherichia coli dihydroxy-acid dehydratase.
    2. This approach identified the comprehensive E. coli NO response network and evinced that nitric oxide (NO) halts bacterial growth via inhibition of the branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase.
      Title: Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroxy-acid dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dihydroxy-acid dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydro-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-valine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branched-chain amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isoleucine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydroxy-acid dehydratase
    YP_026248.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3953478..3955328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026248.1 dihydroxy-acid dehydratase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026248.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FUL6
      Conserved Domains (1) summary
      PRK12448
      Location:2 → 616
      PRK12448; dihydroxy-acid dehydratase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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