Has3 hyaluronan synthase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Has3provided by RGD
Official Full Name: hyaluronan synthase 3provided by RGD
Primary source: RGD:628656
See related: AllianceGenome:RGD:628656
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hyaluronan synthase activity and identical protein binding activity. Predicted to be involved in several processes, including extracellular polysaccharide biosynthetic process; hyaluronan biosynthetic process; and positive regulation of hyaluranon cable assembly. Predicted to be located in Golgi apparatus; hyaluranon cable; and nucleus. Predicted to be active in plasma membrane. Biomarker of pulmonary hypertension. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 38.9), Thymus (RPKM 36.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (51668276..51691042)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (34768421..34782170)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (39063298..39077745)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that p38 and Ca(2+)/calmodulin-dependent protein kinase II pathways were found to be involved in the UVB-induced up-regulation of Has2 and Has3 expression.
Title: Low dose ultraviolet B irradiation increases hyaluronan synthesis in epidermal keratinocytes via sequential induction of hyaluronan synthases Has1-3 mediated by p38 and Ca2+/calmodulin-dependent protein kinase II (CaMKII) signaling.
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Title: Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Epidermal hyaluronan synthesis, controlled by epidermal growth factor and transforming growth factor beta through changes in expression of Has2 and Has3, correlates with epidermal proliferation, thickness, and differentiation.
Title: EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation.
protein malnutrition has a primary impact on the gene expression of Has2 and Has3, which leads to the reduction of hyaluronan content and to disfunction of the skin
Title: Dietary protein as a potent regulator of the hyaluronan synthase gene in rat skin.
belongs to the targets of keratinocyte growth factor in keratinocytes, and support the idea that enhanced hyaluronan synthesis acts an effector for the migratory response of keratinocytes in wound healing
Title: Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hyaluronan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronan synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in extracellular matrix assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluranon cable assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in hyaluranon cable	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hyaluronan synthase 3

NP_758822.1

EC 2.4.1.212

XP_006255623.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172319.1 → NP_758822.1 hyaluronan synthase 3

See identical proteins and their annotated locations for NP_758822.1

Status: PROVISIONAL

Source sequence(s)

AB097569

UniProtKB/TrEMBL

A6IYX8, Q8CH92

Conserved Domains (1) summary

cd06434
Location:87 → 365

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan