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    pflC putative pyruvate formate-lyase 2 activating enzyme PflC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948453, updated on 3-Dec-2024

    Summary

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    Official Symbol
    pflC
    Official Full Name
    putative pyruvate formate-lyase 2 activating enzyme PflC
    Primary source
    ECOCYC:EG11911
    Locus tag
    b3952
    See related
    ASAP:ABE-0012937
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3943; yijM
    Summary
    Radical SAM superfamily. [More information is available at EcoGene: EG11911]. PflC was identified by sequence similarity as a homolog of pyruvate formate-lyase activating enzyme . [More information is available at EcoCyc: EG11911].
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    Genomic context

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    Sequence:
    NC_000913.3 (4146258..4147136)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative PTS enzyme IIC component FrwC Neighboring gene putative PTS enzyme IIB component FrwB Neighboring gene putative formate acetyltransferase 2 Neighboring gene putative PTS enzyme IIB component FrwD Neighboring gene putative DNA-binding transcriptional regulator YijO Neighboring gene phosphoethanolamine transferase EptC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Promoter 7 of the Escherichia coli pfl operon is a major determinant in the anaerobic regulation of expression by ArcA. Drapal N, et al. J Bacteriol, 1995 Sep. PMID 7665524, Free PMC Article
    2. Fumarate reductase mutants of Escherichia coli that lack covalently bound flavin. Blaut M, et al. J Biol Chem, 1989 Aug 15. PMID 2668268
    3. Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system. Reizer J, et al. Microbiology (Reading), 1995 Apr. PMID 7773398
    4. The effect of pfl gene knockout on the metabolism for optically pure D-lactate production by Escherichia coli. Zhu J, et al. Appl Microbiol Biotechnol, 2004 Apr. PMID 14673546
    5. Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes. Blattner FR, et al. Nucleic Acids Res, 1993 Nov 25. PMID 8265357, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [formate-C-acetyltransferase]-activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative pyruvate formate-lyase 2 activating enzyme PflC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4146258..4147136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418387.3 putative pyruvate formate-lyase 2 activating enzyme PflC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418387.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7BFR1, A0A8S7EIZ6
      Conserved Domains (1) summary
      PRK10076
      Location:80 → 292
      PRK10076; pyruvate formate lyase II activase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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