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    GTF2F1 general transcription factor IIF subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2962, updated on 3-Dec-2024

    Summary

    Official Symbol
    GTF2F1provided by HGNC
    Official Full Name
    general transcription factor IIF subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4652
    See related
    Ensembl:ENSG00000125651 MIM:189968; AllianceGenome:HGNC:4652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BTF4; RAP74; TF2F1; TFIIF
    Summary
    Enables several functions, including RNA polymerase II general transcription initiation factor activity; phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II; response to virus; and transcription by RNA polymerase II. Located in cell junction and nucleoplasm. Part of transcription factor TFIID complex and transcription factor TFIIF complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 36.8), testis (RPKM 30.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GTF2F1 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (6379572..6393164, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (6368474..6382065, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6379583..6393175, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6362217-6363174 Neighboring gene caseinolytic mitochondrial matrix peptidase proteolytic subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6372537-6373459 Neighboring gene alkB homolog 7 Neighboring gene persephin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:6387043-6387543 Neighboring gene microRNA 6885 Neighboring gene adenylate kinase isoenzyme 1-like Neighboring gene microRNA 6790 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6411708-6412532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:6412533-6413357 Neighboring gene KH-type splicing regulatory protein Neighboring gene microRNA 3940

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of general transcription factor IIF, polypeptide 1 (GTF2F1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    Tat tat HIV-1 Tat inhibits the binding of RAP74 amino acids 436-517 to FCP1 PubMed
    tat HIV-1 Tat stimulates the phosphorylation of TFIIF subunit RAP74 by TAFII250 during Tat-mediated transcription of the HIV-1 LTR promoter PubMed
    tat TFIIF is required for both basal and HIV-1 Tat-activated transcription PubMed
    tat TFIIF synergizes with HIV-1 Tat and the cellular co-activator Tat-SF1 during Tat-mediated transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIF, during Tat-mediated transactivation of the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription factor TFIIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    general transcription factor IIF subunit 1
    Names
    TFIIF-alpha
    general transcription factor IIF 74 kDa subunit
    general transcription factor IIF, polypeptide 1, 74kDa
    transcription initiation factor IIF subunit alpha
    transcription initiation factor RAP74

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002096.3NP_002087.2  general transcription factor IIF subunit 1

      See identical proteins and their annotated locations for NP_002087.2

      Status: VALIDATED

      Source sequence(s)
      BC013007, X64002, X64037
      Consensus CDS
      CCDS12165.1
      UniProtKB/Swiss-Prot
      B2RCS0, P35269, Q9BWN0
      UniProtKB/TrEMBL
      Q6IBK5
      Related
      ENSP00000377969.3, ENST00000394456.10
      Conserved Domains (1) summary
      pfam05793
      Location:2517
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      6379572..6393164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438710.1XP_047294666.1  general transcription factor IIF subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q6IBK5
      Related
      ENSP00000469091.1, ENST00000593678.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      6368474..6382065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320759.1XP_054176734.1  general transcription factor IIF subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q6IBK5