U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    INPP5F inositol polyphosphate-5-phosphatase F [ Homo sapiens (human) ]

    Gene ID: 22876, updated on 3-Dec-2024

    Summary

    Official Symbol
    INPP5Fprovided by HGNC
    Official Full Name
    inositol polyphosphate-5-phosphatase Fprovided by HGNC
    Primary source
    HGNC:HGNC:17054
    See related
    Ensembl:ENSG00000198825 MIM:609389; AllianceGenome:HGNC:17054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAC2; hSAC2; MSTP007; MSTPO47
    Summary
    The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in brain (RPKM 17.8), testis (RPKM 4.5) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See INPP5F in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119726050..119829147)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (120623626..120726730)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121485562..121588659)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902513 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121443219-121443398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:121446148-121447084 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121447085-121448021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:121451095-121451594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4131 Neighboring gene thioredoxin pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121471328-121471517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121480870-121481758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2881 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121492744-121493244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121497641-121498186 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121498187-121498732 Neighboring gene Sharpr-MPRA regulatory region 1472 Neighboring gene RNA, 7SL, cytoplasmic 846, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8600 Neighboring gene uncharacterized LOC105378513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2882 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2883 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10184 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:121575109-121575271 Neighboring gene phosphatase and actin regulator 2 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121610009-121610508 Neighboring gene minichromosome maintenance complex binding protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4133 Neighboring gene NANOG hESC enhancer GRCh37_chr10:121648618-121649156 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121650957-121651468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:121651469-121651979 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:121651980-121652490 Neighboring gene SEC23 interacting protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10320 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10351

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of inositol polyphosphate-5-phosphatase F (INPP5F) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13081, KIAA0966, MGC59773, MGC131851

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac muscle hypertrophy in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in phosphatidylinositol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of receptor recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in clathrin-coated endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in clathrin-coated endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    phosphatidylinositide phosphatase SAC2
    Names
    Sac domain-containing inositol phosphatase 2
    sac domain-containing phosphoinositide 4-phosphatase 2
    sac domain-containing phosphoinositide 5-phosphatase 2
    NP_001230123.1
    NP_001230124.1
    NP_055752.1
    XP_006717783.1
    XP_011537829.2
    XP_011537830.1
    XP_011537831.1
    XP_047280790.1
    XP_047280792.1
    XP_047280793.1
    XP_047280794.1
    XP_054221199.1
    XP_054221200.1
    XP_054221201.1
    XP_054221202.1
    XP_054221203.1
    XP_054221204.1
    XP_054221205.1
    XP_054221206.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_044999.2 RefSeqGene

      Range
      26656..129753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1061

    mRNA and Protein(s)

    1. NM_001243194.2NP_001230123.1  phosphatidylinositide phosphatase SAC2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC027672, AL133461, CN362016, DN992317
      Consensus CDS
      CCDS58098.1
      UniProtKB/Swiss-Prot
      Q9Y2H2
      Related
      ENSP00000496955.1, ENST00000650409.1
      Conserved Domains (1) summary
      pfam12456
      Location:1987
      hSac2; Inositol phosphatase
    2. NM_001243195.2NP_001230124.1  phosphatidylinositide phosphatase SAC2 isoform 3

      See identical proteins and their annotated locations for NP_001230124.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI492073, AI783668, AL158014, BC052367, DB636424
      Consensus CDS
      CCDS81513.1
      UniProtKB/Swiss-Prot
      Q9Y2H2
      Related
      ENSP00000489864.1, ENST00000369081.3
      Conserved Domains (1) summary
      cl27434
      Location:50199
      Syja_N; SacI homology domain
    3. NM_014937.4NP_055752.1  phosphatidylinositide phosphatase SAC2 isoform 1

      See identical proteins and their annotated locations for NP_055752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB023183, AC027672, AL158014
      Consensus CDS
      CCDS7616.1
      UniProtKB/Swiss-Prot
      B3KRF1, D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51, Q9Y2H2
      UniProtKB/TrEMBL
      A0A3B3IRJ9
      Related
      ENSP00000497527.1, ENST00000650623.2
      Conserved Domains (2) summary
      COG5329
      Location:50567
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam12456
      Location:596697
      hSac2; Inositol phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      119726050..119829147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717720.5XP_006717783.1  phosphatidylinositide phosphatase SAC2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3ISI3
      Related
      ENSP00000497368.1, ENST00000649251.1
      Conserved Domains (2) summary
      pfam12456
      Location:595629
      hSac2; Inositol phosphatase
      cl27434
      Location:50567
      Syja_N; SacI homology domain
    2. XM_047424834.1XP_047280790.1  phosphatidylinositide phosphatase SAC2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRJ9, A0A3B3ITL0
    3. XM_047424836.1XP_047280792.1  phosphatidylinositide phosphatase SAC2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRJ9, A0A3B3ITL0
      Related
      ENSP00000497772.1, ENST00000647699.1
    4. XM_047424837.1XP_047280793.1  phosphatidylinositide phosphatase SAC2 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRJ9
    5. XM_011539527.4XP_011537829.2  phosphatidylinositide phosphatase SAC2 isoform X1

      UniProtKB/TrEMBL
      A0A3B3IRJ9
    6. XM_011539528.4XP_011537830.1  phosphatidylinositide phosphatase SAC2 isoform X2

      See identical proteins and their annotated locations for XP_011537830.1

      UniProtKB/TrEMBL
      A0A3B3IRJ9, A0A3B3ITL0
      Related
      ENSP00000497846.1, ENST00000649454.1
      Conserved Domains (2) summary
      pfam02383
      Location:73319
      Syja_N; SacI homology domain
      pfam12456
      Location:499601
      hSac2; Inositol phosphatase
    7. XM_047424838.1XP_047280794.1  phosphatidylinositide phosphatase SAC2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3IRJ9
    8. XM_011539529.3XP_011537831.1  phosphatidylinositide phosphatase SAC2 isoform X5

      Conserved Domains (1) summary
      pfam12456
      Location:109211
      hSac2; Inositol phosphatase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      120623626..120726730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365231.1XP_054221206.1  phosphatidylinositide phosphatase SAC2 isoform X6

      UniProtKB/TrEMBL
      A0A3B3ISI3
    2. XM_054365225.1XP_054221200.1  phosphatidylinositide phosphatase SAC2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRJ9, A0A3B3ITL0
    3. XM_054365226.1XP_054221201.1  phosphatidylinositide phosphatase SAC2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRJ9, A0A3B3ITL0
    4. XM_054365228.1XP_054221203.1  phosphatidylinositide phosphatase SAC2 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRJ9
    5. XM_054365224.1XP_054221199.1  phosphatidylinositide phosphatase SAC2 isoform X1

      UniProtKB/TrEMBL
      A0A3B3IRJ9
    6. XM_054365227.1XP_054221202.1  phosphatidylinositide phosphatase SAC2 isoform X2

      UniProtKB/TrEMBL
      A0A3B3IRJ9, A0A3B3ITL0
    7. XM_054365229.1XP_054221204.1  phosphatidylinositide phosphatase SAC2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3IRJ9
    8. XM_054365230.1XP_054221205.1  phosphatidylinositide phosphatase SAC2 isoform X5